Tropoxine in the effective dose does not affect on activity of CYP2С9 and CYP1А2 isoforms of cytochrome P450 in rats
Effects of tropoxine on activity of isoforms CYP2С9 and CYP2С9 of cytochrome P450 using marker drugs losartane and caffeine were studied. Tropoxine in the effective dose (30 mg/kg) after 4-days intraperitoneal administration (3 times per day) in rats did not produce changes of CYP2C9 and CYP1A2 isof...
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2017-11-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/39 |
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| author | V. P. Zherdev G. B. Kolyvanov A. A. Litvin O. G. Grybakina P. O. Bochkov R. V. Shevchenko |
| author_facet | V. P. Zherdev G. B. Kolyvanov A. A. Litvin O. G. Grybakina P. O. Bochkov R. V. Shevchenko |
| author_sort | V. P. Zherdev |
| collection | DOAJ |
| description | Effects of tropoxine on activity of isoforms CYP2С9 and CYP2С9 of cytochrome P450 using marker drugs losartane and caffeine were studied. Tropoxine in the effective dose (30 mg/kg) after 4-days intraperitoneal administration (3 times per day) in rats did not produce changes of CYP2C9 and CYP1A2 isoforms actitvity. Study of duration of tropoxine administration on the CYP2C9 acivity changing was shown that 3 and 4 days administration of the drug did not affect neither inhibiting nor inducing effect of CYP2C9 isoform. |
| format | Article |
| id | doaj-art-96b5247ff5104a33a4e40b0914f2ecf4 |
| institution | Matheson Library |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2017-11-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-96b5247ff5104a33a4e40b0914f2ecf42025-08-03T13:00:45ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302017-11-0104121538Tropoxine in the effective dose does not affect on activity of CYP2С9 and CYP1А2 isoforms of cytochrome P450 in ratsV. P. Zherdev0G. B. Kolyvanov1A. A. Litvin2O. G. Grybakina3P. O. Bochkov4R. V. Shevchenko5ФГБНУ «НИИ фармакологии имени В.В. Закусова»ФГБНУ «НИИ фармакологии имени В.В. Закусова»ФГБНУ «НИИ фармакологии имени В.В. Закусова»ФГБНУ «НИИ фармакологии имени В.В. Закусова»ФГБНУ «НИИ фармакологии имени В.В. Закусова»ФГБНУ «НИИ фармакологии имени В.В. Закусова»Effects of tropoxine on activity of isoforms CYP2С9 and CYP2С9 of cytochrome P450 using marker drugs losartane and caffeine were studied. Tropoxine in the effective dose (30 mg/kg) after 4-days intraperitoneal administration (3 times per day) in rats did not produce changes of CYP2C9 and CYP1A2 isoforms actitvity. Study of duration of tropoxine administration on the CYP2C9 acivity changing was shown that 3 and 4 days administration of the drug did not affect neither inhibiting nor inducing effect of CYP2C9 isoform.https://www.pharmacokinetica.ru/jour/article/view/39тропоксинcyp2с9cyp1а2лозартанкофеинметаболическое отношениемежлекарственное взаимодействиеtropoxinecyp2с9cyp1a2losartanecaffeinemetabolic ratiodrug-drug interaction |
| spellingShingle | V. P. Zherdev G. B. Kolyvanov A. A. Litvin O. G. Grybakina P. O. Bochkov R. V. Shevchenko Tropoxine in the effective dose does not affect on activity of CYP2С9 and CYP1А2 isoforms of cytochrome P450 in rats Фармакокинетика и Фармакодинамика тропоксин cyp2с9 cyp1а2 лозартан кофеин метаболическое отношение межлекарственное взаимодействие tropoxine cyp2с9 cyp1a2 losartane caffeine metabolic ratio drug-drug interaction |
| title | Tropoxine in the effective dose does not affect on activity of CYP2С9 and CYP1А2 isoforms of cytochrome P450 in rats |
| title_full | Tropoxine in the effective dose does not affect on activity of CYP2С9 and CYP1А2 isoforms of cytochrome P450 in rats |
| title_fullStr | Tropoxine in the effective dose does not affect on activity of CYP2С9 and CYP1А2 isoforms of cytochrome P450 in rats |
| title_full_unstemmed | Tropoxine in the effective dose does not affect on activity of CYP2С9 and CYP1А2 isoforms of cytochrome P450 in rats |
| title_short | Tropoxine in the effective dose does not affect on activity of CYP2С9 and CYP1А2 isoforms of cytochrome P450 in rats |
| title_sort | tropoxine in the effective dose does not affect on activity of cyp2с9 and cyp1а2 isoforms of cytochrome p450 in rats |
| topic | тропоксин cyp2с9 cyp1а2 лозартан кофеин метаболическое отношение межлекарственное взаимодействие tropoxine cyp2с9 cyp1a2 losartane caffeine metabolic ratio drug-drug interaction |
| url | https://www.pharmacokinetica.ru/jour/article/view/39 |
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