Bone Mineral Density and Vitamin D Status in Elderly Javanese Women
Background: Vitamin D (25OHD) works as a lipid-soluble secosteroid hormone essential for metabolic activities, including bone mineralization. 1,25OHD and its receptor are transcription factors for various bone homeostasis genes. Numerous studies have connected vitamin D insufficiency with a decline...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine, Universitas Diponegoro
2023-05-01
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| Series: | Jurnal Kedokteran Diponegoro |
| Subjects: | |
| Online Access: | https://ejournal3.undip.ac.id/index.php/medico/article/view/38663 |
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| Summary: | Background: Vitamin D (25OHD) works as a lipid-soluble secosteroid hormone essential for metabolic activities, including bone mineralization. 1,25OHD and its receptor are transcription factors for various bone homeostasis genes. Numerous studies have connected vitamin D insufficiency with a decline in bone mineral density (BMD), but the results are still conflicting. However, information on vitamin D insufficiency among Indonesian individuals is hardly available.
Objective: The study aims to evaluate vitamin D levels and their correlation with BMD among Javanese elderly women.
Methods: 75 healthy Javanese elderly women between 60 and 84 participated in a cross-sectional study. An enzyme-linked immunoassay kit for 25OHD was used to measure the level of serum vitamin D. DXA, or dual-energy X-ray absorptiometry, was used to measure BMD.
Results: The study population's mean serum 25OHD level was 14.97±6.6ng/mL. We found that 73.3% were deficient in vitamin D, and 26.7% were not. There is no correlation between vitamin D and BMD L-spine, F-neck, or T-score (p=0.064, -0.215; p=0.443, -0.090; and p=0.109, -0.187, respectively). Lower BMD L-spine, F-neck and T-score were correlated with increased age (r = -0.238, p = 0.040; r = -0.377, p = 0.001; and r = -0.295, p = 0.010, respectively) and decreased BMI (r = 0.525, p = 0.000; r = 0.516, p = 0.000; and r = 0.520, p = 0.000, respectively).
Conclusion: From this study, we concluded that vitamin D deficiency was prevalent among Javanese elderly women. However, the vitamin D level in this population and bone mineral density do not appear to be correlated. |
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| ISSN: | 2540-8844 |