Effects of fermented brewer's spent grains on growth performance, intestinal development and liver metabolism in broilers
This study was conducted to investigate the effects of graded levels of wet-fermented brewer's grains (WFBG) on growth performance, gut development, and metabolism profiles in white-feathered broilers. A total of 480 broilers (36.46 ± 0.93 g, male, 1-d-old) were randomly allocated into 5 treatm...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-10-01
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| Series: | Journal of Agriculture and Food Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666154325005277 |
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| Summary: | This study was conducted to investigate the effects of graded levels of wet-fermented brewer's grains (WFBG) on growth performance, gut development, and metabolism profiles in white-feathered broilers. A total of 480 broilers (36.46 ± 0.93 g, male, 1-d-old) were randomly allocated into 5 treatments (0 %, 5 %, 10 %, 20 %, or 30 % WFBG) (six replicates of 16 birds each). During the entire experimental period, the average daily gain (ADG) in the 30 % WFBG group was significantly lower than that in the 0 %, 5 %, 10 %, and 20 % WFBG groups (P < 0.05). Birds fed 30 % WFBG had lower adjusted average daily feed intake (ADFI) compared with the 0 %, 5 %, 10 %, and 20 % WFBG groups (P < 0.05). The adjusted feed conversion ratio (FCR) in the 30 % WFBG group was significantly lower than those in the 0 %, 10 % and 20 % WFBG groups (P < 0.05). Feeding 20 % WFBG increased (P < 0.05) the duodenal development. With the application of untargeted metabolomics, 504 serum differentially-expressed metabolites (DEMs) and 185 liver DEMs were identified. Metabolic pathway analysis revealed the potential serum and liver DEMs involved in 45 metabolic pathways, including amino acid metabolism, carbohydrate metabolism and lipid metabolism in broilers. In addition, the negative effect of high-dose WFBG on the birds may be largely mediated by glycine, serine and threonine metabolism pathway. These results suggested the potential biomarkers involved in pathogenesis of intestinal injuries induced by 30 % WFBG. The optimal dosage of WFBG added to broiler chicken feed should not exceed 20 %. |
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| ISSN: | 2666-1543 |