Aloe-emodin mediates the inhibitory effect of LncRNA D63785 on the PI3K/Akt/mTOR pathway in nasopharyngeal carcinoma

Aloe-emodin mediates the inhibitory effect of LncRNA D63785 on the PI3K/Akt/mTOR pathway in nasopharyngeal carcinoma

BackgroundLong non-coding RNAs (lncRNAs) are dysregulated in nasopharyngeal carcinoma (NPC), yet their interplay with pharmacological agents like aloe-emodin (AE) remains unclear. This study explores AE’s anti-NPC mechanisms via lncRNA D63785 and the PI3K/Akt/mTOR pathway.MethodsNPC cells (CNE1, C66...

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Bibliographic Details
Main Authors: Min He, Lei Xie, Jiayi Huang, Han Su, Jiahua Hu, Liuping Xie, Mengqin Li, Xin Zeng, Jianhong Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
AE
NPC
LncRNA D63785
PI3K/Akt/mTOR signaling pathway
proliferation and migration
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1573408/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1573408/full

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