Candidiasis in breast cancer: Tumor progression or not?
Candida albicans is an “opportunistic fungal agent” in cancer patients that can become colonized in both mucosal and deep tissues and cause severe infections. Most evidence has shown that C. albicans can enhance the progress of different cancers by several mechanisms such as generating virulence fac...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2024-11-01
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| Series: | Iranian Journal of Basic Medical Sciences |
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| Online Access: | https://ijbms.mums.ac.ir/article_24602_1fab875578ffbfb03562c3ea121da363.pdf |
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| author | Somayeh Ashrafi Abbas Ali Amini Pegah Karimi Maryam Bagherian Mohammad Mahdi Adibzadeh Sereshgi Fatemeh Asgarhalvaei Khadijeh Ahmadi Mohammad Hossein Yazdi Hamidreza Jahantigh Mehdi Mahdavi Ramin Sarrami Forooshani |
| author_facet | Somayeh Ashrafi Abbas Ali Amini Pegah Karimi Maryam Bagherian Mohammad Mahdi Adibzadeh Sereshgi Fatemeh Asgarhalvaei Khadijeh Ahmadi Mohammad Hossein Yazdi Hamidreza Jahantigh Mehdi Mahdavi Ramin Sarrami Forooshani |
| author_sort | Somayeh Ashrafi |
| collection | DOAJ |
| description | Candida albicans is an “opportunistic fungal agent” in cancer patients that can become colonized in both mucosal and deep tissues and cause severe infections. Most evidence has shown that C. albicans can enhance the progress of different cancers by several mechanisms such as generating virulence factors, participation in endogenous production of pro-inflammatory mediators, and stimulating a wide range of immune cells in the host. The main idea of this review is to describe a range of Candida-used mechanisms that are important in candidiasis-associated malignant processes and cancer development, particularly breast cancer. This review intends to provide a detailed discussion on different regulatory mechanisms of C. albicans that undoubtedly help to open new therapeutic horizons of cancer therapy in patients with fungal infection. The current therapeutic approach is not fully effective in immunocompromised and cancer patients, and further studies are required to find new products with effective antifungal properties and minimal side effects to increase the susceptibility of opportunistic fungal infections to conventional antifungal agents. So, in this situation, a special therapy should be considered to control the infection and simultaneously have the most therapeutic index on tumor patients. |
| format | Article |
| id | doaj-art-94e86237e98a405fa50d632e51b617a5 |
| institution | Matheson Library |
| issn | 2008-3866 2008-3874 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj-art-94e86237e98a405fa50d632e51b617a52025-07-27T09:50:45ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742024-11-0127111346135610.22038/ijbms.2024.75408.1637924602Candidiasis in breast cancer: Tumor progression or not?Somayeh Ashrafi0Abbas Ali Amini1Pegah Karimi2Maryam Bagherian3Mohammad Mahdi Adibzadeh Sereshgi4Fatemeh Asgarhalvaei5Khadijeh Ahmadi6Mohammad Hossein Yazdi7Hamidreza Jahantigh8Mehdi Mahdavi9Ramin Sarrami Forooshani10Advanced Therapy Medicinal Product (ATMP) Department, Breast Cancer Research Center, Motamed Cancer Institute, Academic Center for Education, Culture and Research (ACECR), Tehran, IranDepartment of Immunology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, IranAdvanced Therapy Medicinal Product (ATMP) Department, Breast Cancer Research Center, Motamed Cancer Institute, Academic Center for Education, Culture and Research (ACECR), Tehran, IranDepartment of Hematology and Oncology and Stem Cell Transplantation, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, IranDepartment of Immunology, Shahed University, Tehran, IranDepartment of Microbiology, Faculty of Advanced Sciences & Technology, Tehran Medical Sciences, Islamic Azad University, (IAUPS), Tehran, IranInfectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, IranRecombinant Vaccine Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranAnimal Health and Zoonosis PhD Course, Department of Veterinary Medicine, University of Bari, Bari, ItalyAdvanced Therapy Medicinal Product (ATMP) Department, Breast Cancer Research Center, Motamed Cancer Institute, Academic Center for Education, Culture and Research (ACECR), Tehran, IranAdvanced Therapy Medicinal Product (ATMP) Department, Breast Cancer Research Center, Motamed Cancer Institute, Academic Center for Education, Culture and Research (ACECR), Tehran, IranCandida albicans is an “opportunistic fungal agent” in cancer patients that can become colonized in both mucosal and deep tissues and cause severe infections. Most evidence has shown that C. albicans can enhance the progress of different cancers by several mechanisms such as generating virulence factors, participation in endogenous production of pro-inflammatory mediators, and stimulating a wide range of immune cells in the host. The main idea of this review is to describe a range of Candida-used mechanisms that are important in candidiasis-associated malignant processes and cancer development, particularly breast cancer. This review intends to provide a detailed discussion on different regulatory mechanisms of C. albicans that undoubtedly help to open new therapeutic horizons of cancer therapy in patients with fungal infection. The current therapeutic approach is not fully effective in immunocompromised and cancer patients, and further studies are required to find new products with effective antifungal properties and minimal side effects to increase the susceptibility of opportunistic fungal infections to conventional antifungal agents. So, in this situation, a special therapy should be considered to control the infection and simultaneously have the most therapeutic index on tumor patients.https://ijbms.mums.ac.ir/article_24602_1fab875578ffbfb03562c3ea121da363.pdfbreast cancercancer therapycandida albicansimmune responsestumor progression |
| spellingShingle | Somayeh Ashrafi Abbas Ali Amini Pegah Karimi Maryam Bagherian Mohammad Mahdi Adibzadeh Sereshgi Fatemeh Asgarhalvaei Khadijeh Ahmadi Mohammad Hossein Yazdi Hamidreza Jahantigh Mehdi Mahdavi Ramin Sarrami Forooshani Candidiasis in breast cancer: Tumor progression or not? Iranian Journal of Basic Medical Sciences breast cancer cancer therapy candida albicans immune responses tumor progression |
| title | Candidiasis in breast cancer: Tumor progression or not? |
| title_full | Candidiasis in breast cancer: Tumor progression or not? |
| title_fullStr | Candidiasis in breast cancer: Tumor progression or not? |
| title_full_unstemmed | Candidiasis in breast cancer: Tumor progression or not? |
| title_short | Candidiasis in breast cancer: Tumor progression or not? |
| title_sort | candidiasis in breast cancer tumor progression or not |
| topic | breast cancer cancer therapy candida albicans immune responses tumor progression |
| url | https://ijbms.mums.ac.ir/article_24602_1fab875578ffbfb03562c3ea121da363.pdf |
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