Depolymerization of tubulin as the main molecular mechanism of the cytotoxic and antitumor activity of pyrrole-containing heterocyclic compounds

Depolymerization of tubulin as the main molecular mechanism of the cytotoxic and antitumor activity of pyrrole-containing heterocyclic compounds

Introduction. Microtubules are highly dynamic polymers of α, β-tubulin dimers involves in a broad spectrum of the processes, such as intracellular transport and cell proliferation. This makes them an attractive molecular target for anti-cancer therapies. Substances that affect the dynamic state of t...

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Main Authors: A. R. Galembikova, P. D. Dunaev, T. V. Ivoilova, A. I. Gilyazova, A. E. Galyautdinova, E. G. Mikheeva, S. S. Zykova, N. M. Igidov, P. B. Kopnin, S. V. Boichuk
Format: Article
Language:Russian
Published: ABV-press 2024-06-01
Series:Успехи молекулярной онкологии
Subjects:
microtubules
tubulin depolymerization
cell cycle
apoptosis
mitotic catastrophe
multidrug resistance
triple-negative breast cancer
gastrointestinal stromal tumor
osteosarcoma
colorectal adenocarcinoma
ethyl-pyrrole-carboxyls
pyrrole-carboxamides
paclitaxel
vinblastine
doxorubicin
Online Access:https://umo.abvpress.ru/jour/article/view/683
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