Change of Toxic Properties of the Methotrexate when Exposed to Extreme Temperatures During Development of Drosophila melanogaster
The results of the experiments show that a nutrient medium with the methotrexate has influence both on generative and on somatic cells of drosophila, depending on the concentration of this drug in a medium. Moreover, the higher temperature during development of drosophila can increase toxic properti...
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| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
| Subjects: | |
| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/149 |
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| Summary: | The results of the experiments show that a nutrient medium with the methotrexate has influence both on generative and on somatic cells of drosophila, depending on the concentration of this drug in a medium. Moreover, the higher temperature during development of drosophila can increase toxic properties of a methotrexate, which was observed based on an analysis of fertility of the flies developing in the environment with addition of a methotrexate, but no negative cumulative effect of cytostatic and elevated temperature were found in relation to lethality rate of the offspring. A negative effect on viability indicators was also not registered with the combined effects of the cytostatic and low temperature. |
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| ISSN: | 0235-2990 |