Pharmacokinetics Of Zinc In Broiler Chickens After Single Intraingluvial Administration With Zinc Aspartate
The pharmacokinetics of zinc was investigated in broiler chickens after single crop intubation of 50 mg/kg 5% zinc aspartate suspension in 2% carboxymethyl cellulose solution. Blood serum zinc concentrations were assayed on a biochemical analyzer. The pharmacokinetics of zinc was evaluated using two...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Medical University - Pleven
2014-12-01
|
| Series: | Journal of Biomedical & Clinical Research |
| Subjects: | |
| Online Access: | https://jbcr.arphahub.com/article/34341/download/pdf/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839613446366167040 |
|---|---|
| author | Sofiya Ivanova Dimitrichka Dimitrova Metodi Petrichev Liliana Parvanova Georgi Kalistratov Lubomir Vezenkov |
| author_facet | Sofiya Ivanova Dimitrichka Dimitrova Metodi Petrichev Liliana Parvanova Georgi Kalistratov Lubomir Vezenkov |
| author_sort | Sofiya Ivanova |
| collection | DOAJ |
| description | The pharmacokinetics of zinc was investigated in broiler chickens after single crop intubation of 50 mg/kg 5% zinc aspartate suspension in 2% carboxymethyl cellulose solution. Blood serum zinc concentrations were assayed on a biochemical analyzer. The pharmacokinetics of zinc was evaluated using two approaches – compartmental method and non-compartmental analysis using pharmacokinetic software (TopFit, v. 2.0). After the intraingluvial application, zinc was rapidly absorbed (t1/2abs. =0.1040.02 h) by the alimentary system of birds attaining Cmax of 63.603.94 mol/ml by hour 0.77 (compartmental method) and Cmax =69.274.35 mol/ml by hour 0.92 h (non-compartmental method). It is characterized with a long biological half-life (t1/2) of 13.821.63 h (compartmental analysis) and 15.961.73 h (non-compartmental analysis) and long mean residence times (MRT) 20.122.35 h and 23.002.50 h, respectively. The distribution in blood and extracellular fluid was good as seen from Vd(area) values 0.770.05 l/kg (compartmental analysis) and 0.650.05 l/kg (non-compartmental analysis). |
| format | Article |
| id | doaj-art-92a01288d2cc4df2bc4af870a85ec8f7 |
| institution | Matheson Library |
| issn | 1313-9053 |
| language | English |
| publishDate | 2014-12-01 |
| publisher | Medical University - Pleven |
| record_format | Article |
| series | Journal of Biomedical & Clinical Research |
| spelling | doaj-art-92a01288d2cc4df2bc4af870a85ec8f72025-07-27T07:33:00ZengMedical University - PlevenJournal of Biomedical & Clinical Research1313-90532014-12-0172889210.1515/jbcr-2015-013134341Pharmacokinetics Of Zinc In Broiler Chickens After Single Intraingluvial Administration With Zinc AspartateSofiya IvanovaDimitrichka DimitrovaMetodi PetrichevLiliana ParvanovaGeorgi KalistratovLubomir VezenkovThe pharmacokinetics of zinc was investigated in broiler chickens after single crop intubation of 50 mg/kg 5% zinc aspartate suspension in 2% carboxymethyl cellulose solution. Blood serum zinc concentrations were assayed on a biochemical analyzer. The pharmacokinetics of zinc was evaluated using two approaches – compartmental method and non-compartmental analysis using pharmacokinetic software (TopFit, v. 2.0). After the intraingluvial application, zinc was rapidly absorbed (t1/2abs. =0.1040.02 h) by the alimentary system of birds attaining Cmax of 63.603.94 mol/ml by hour 0.77 (compartmental method) and Cmax =69.274.35 mol/ml by hour 0.92 h (non-compartmental method). It is characterized with a long biological half-life (t1/2) of 13.821.63 h (compartmental analysis) and 15.961.73 h (non-compartmental analysis) and long mean residence times (MRT) 20.122.35 h and 23.002.50 h, respectively. The distribution in blood and extracellular fluid was good as seen from Vd(area) values 0.770.05 l/kg (compartmental analysis) and 0.650.05 l/kg (non-compartmental analysis).https://jbcr.arphahub.com/article/34341/download/pdf/pharmacokineticschickenszinc aspartate |
| spellingShingle | Sofiya Ivanova Dimitrichka Dimitrova Metodi Petrichev Liliana Parvanova Georgi Kalistratov Lubomir Vezenkov Pharmacokinetics Of Zinc In Broiler Chickens After Single Intraingluvial Administration With Zinc Aspartate Journal of Biomedical & Clinical Research pharmacokinetics chickens zinc aspartate |
| title | Pharmacokinetics Of Zinc In Broiler Chickens After Single Intraingluvial Administration With Zinc Aspartate |
| title_full | Pharmacokinetics Of Zinc In Broiler Chickens After Single Intraingluvial Administration With Zinc Aspartate |
| title_fullStr | Pharmacokinetics Of Zinc In Broiler Chickens After Single Intraingluvial Administration With Zinc Aspartate |
| title_full_unstemmed | Pharmacokinetics Of Zinc In Broiler Chickens After Single Intraingluvial Administration With Zinc Aspartate |
| title_short | Pharmacokinetics Of Zinc In Broiler Chickens After Single Intraingluvial Administration With Zinc Aspartate |
| title_sort | pharmacokinetics of zinc in broiler chickens after single intraingluvial administration with zinc aspartate |
| topic | pharmacokinetics chickens zinc aspartate |
| url | https://jbcr.arphahub.com/article/34341/download/pdf/ |
| work_keys_str_mv | AT sofiyaivanova pharmacokineticsofzincinbroilerchickensaftersingleintraingluvialadministrationwithzincaspartate AT dimitrichkadimitrova pharmacokineticsofzincinbroilerchickensaftersingleintraingluvialadministrationwithzincaspartate AT metodipetrichev pharmacokineticsofzincinbroilerchickensaftersingleintraingluvialadministrationwithzincaspartate AT lilianaparvanova pharmacokineticsofzincinbroilerchickensaftersingleintraingluvialadministrationwithzincaspartate AT georgikalistratov pharmacokineticsofzincinbroilerchickensaftersingleintraingluvialadministrationwithzincaspartate AT lubomirvezenkov pharmacokineticsofzincinbroilerchickensaftersingleintraingluvialadministrationwithzincaspartate |