Neuroprotective effect of myoinositol on the cellular model of glutamate stress as a basis for the prevention of disorders of intrauterine development of the brain
Myoinositol is the basis for the synthesis of an important group of signal molecules, inositolphosphates, which mediate signal transmission from receptors of growth factors and neurotransmitters. Grants myo-Inositol promote the prevention of folate-resistant defects and neuroprotection of the fetal...
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2019-10-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/64 |
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| author | A. G. Kalacheva I. Yu. Torshin E. V. Stelmashuk E. E. Genrikhs O. P. Alexandrova L. G. Khaspekov O. A. Gromova |
| author_facet | A. G. Kalacheva I. Yu. Torshin E. V. Stelmashuk E. E. Genrikhs O. P. Alexandrova L. G. Khaspekov O. A. Gromova |
| author_sort | A. G. Kalacheva |
| collection | DOAJ |
| description | Myoinositol is the basis for the synthesis of an important group of signal molecules, inositolphosphates, which mediate signal transmission from receptors of growth factors and neurotransmitters. Grants myo-Inositol promote the prevention of folate-resistant defects and neuroprotection of the fetal brain ischemia. The paper presents the results of a study of the effects of myoinositol on the growth of cerebellar neurons in culture under glutamate stress. It is shown that the effects of myoinositol on the survival of neurons (+17 %) exceed the effects of drugs that are usually used for neuroprotection (peptide extracts - + 10 %, choline preparations - no more than 3 %). Confirmed in the present work, a direct neuroprotective effect of myo-Inositol indicates the importance of the use of myo-Inositol during pregnancy with the aim of neuroprotection of the fetal brain. |
| format | Article |
| id | doaj-art-92812f11b3b34b65b6c9e5e31d0288a1 |
| institution | Matheson Library |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2019-10-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-92812f11b3b34b65b6c9e5e31d0288a12025-08-03T13:00:45ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302019-10-010392010.24411/2587-7836-2018-10018.63Neuroprotective effect of myoinositol on the cellular model of glutamate stress as a basis for the prevention of disorders of intrauterine development of the brainA. G. Kalacheva0I. Yu. Torshin1E. V. Stelmashuk2E. E. Genrikhs3O. P. Alexandrova4L. G. Khaspekov5O. A. Gromova6Federal State Budgetary Educational Institution of Higher Education «Ivanovo State Medical Academy» of the Ministry of Healthcare of the Russian FederationFederal Research Center «Computer Science and Control» of the Russian Academy of SciencesResearch Center of NeurologyResearch Center of NeurologyResearch Center of NeurologyResearch Center of NeurologyFederal State Budgetary Educational Institution of Higher Education «Ivanovo State Medical Academy» of the Ministry of Healthcare of the Russian Federation; Federal Research Center «Computer Science and Control» of the Russian Academy of SciencesMyoinositol is the basis for the synthesis of an important group of signal molecules, inositolphosphates, which mediate signal transmission from receptors of growth factors and neurotransmitters. Grants myo-Inositol promote the prevention of folate-resistant defects and neuroprotection of the fetal brain ischemia. The paper presents the results of a study of the effects of myoinositol on the growth of cerebellar neurons in culture under glutamate stress. It is shown that the effects of myoinositol on the survival of neurons (+17 %) exceed the effects of drugs that are usually used for neuroprotection (peptide extracts - + 10 %, choline preparations - no more than 3 %). Confirmed in the present work, a direct neuroprotective effect of myo-Inositol indicates the importance of the use of myo-Inositol during pregnancy with the aim of neuroprotection of the fetal brain.https://www.pharmacokinetica.ru/jour/article/view/64нейроцитологиянейропротекциянейротрофичностьнейропластичностьразвитие мозга плодацитидин-5-дифосфохолинцеребролизинмиоинозитолneurocytologyneuroprotectionneurotrophinesneuroplasticitybrain development of the fetuscytidine-5-diphosphocholinecerebrolysinmyoinositol |
| spellingShingle | A. G. Kalacheva I. Yu. Torshin E. V. Stelmashuk E. E. Genrikhs O. P. Alexandrova L. G. Khaspekov O. A. Gromova Neuroprotective effect of myoinositol on the cellular model of glutamate stress as a basis for the prevention of disorders of intrauterine development of the brain Фармакокинетика и Фармакодинамика нейроцитология нейропротекция нейротрофичность нейропластичность развитие мозга плода цитидин-5-дифосфохолин церебролизин миоинозитол neurocytology neuroprotection neurotrophines neuroplasticity brain development of the fetus cytidine-5-diphosphocholine cerebrolysin myoinositol |
| title | Neuroprotective effect of myoinositol on the cellular model of glutamate stress as a basis for the prevention of disorders of intrauterine development of the brain |
| title_full | Neuroprotective effect of myoinositol on the cellular model of glutamate stress as a basis for the prevention of disorders of intrauterine development of the brain |
| title_fullStr | Neuroprotective effect of myoinositol on the cellular model of glutamate stress as a basis for the prevention of disorders of intrauterine development of the brain |
| title_full_unstemmed | Neuroprotective effect of myoinositol on the cellular model of glutamate stress as a basis for the prevention of disorders of intrauterine development of the brain |
| title_short | Neuroprotective effect of myoinositol on the cellular model of glutamate stress as a basis for the prevention of disorders of intrauterine development of the brain |
| title_sort | neuroprotective effect of myoinositol on the cellular model of glutamate stress as a basis for the prevention of disorders of intrauterine development of the brain |
| topic | нейроцитология нейропротекция нейротрофичность нейропластичность развитие мозга плода цитидин-5-дифосфохолин церебролизин миоинозитол neurocytology neuroprotection neurotrophines neuroplasticity brain development of the fetus cytidine-5-diphosphocholine cerebrolysin myoinositol |
| url | https://www.pharmacokinetica.ru/jour/article/view/64 |
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