SAMHD1 enhances HIV-1-induced apoptosis in monocytic cells via the mitochondrial pathway

SAMHD1 enhances HIV-1-induced apoptosis in monocytic cells via the mitochondrial pathway

ABSTRACT Sterile alpha motif (SAM) and histidine-aspartate (HD) domain-containing protein 1 (SAMHD1) inhibits HIV-1 replication in non-dividing cells by reducing the intracellular dNTP pool. While SAMHD1 is known to promote spontaneous apoptosis, its role in HIV-1-induced apoptosis and the underlyin...

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Bibliographic Details
Main Authors: Hua Yang, Pak-Hin Hinson Cheung, Li Wu
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mBio
Subjects:
SAMHD1
HIV-1 infection
apoptosis
THP-1 cells
monocytic cells
mitochondrial membrane potential
Online Access:https://journals.asm.org/doi/10.1128/mbio.00425-25
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