A Review of Non-Fully Supervised Deep Learning for Medical Image Segmentation

Medical image segmentation, a critical task in medical image analysis, aims to precisely delineate regions of interest (ROIs) such as organs, lesions, and cells, and is crucial for applications including computer-aided diagnosis, surgical planning, radiation therapy, and pathological analysis. While...

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Main Authors: Xinyue Zhang, Jianfeng Wang, Jinqiao Wei, Xinyu Yuan, Ming Wu
Format: Article
Language:English
Published: MDPI AG 2025-05-01
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Online Access:https://www.mdpi.com/2078-2489/16/6/433
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author Xinyue Zhang
Jianfeng Wang
Jinqiao Wei
Xinyu Yuan
Ming Wu
author_facet Xinyue Zhang
Jianfeng Wang
Jinqiao Wei
Xinyu Yuan
Ming Wu
author_sort Xinyue Zhang
collection DOAJ
description Medical image segmentation, a critical task in medical image analysis, aims to precisely delineate regions of interest (ROIs) such as organs, lesions, and cells, and is crucial for applications including computer-aided diagnosis, surgical planning, radiation therapy, and pathological analysis. While fully supervised deep learning methods have demonstrated remarkable performance in this domain, their reliance on large-scale, pixel-level annotated datasets—a significant label scarcity challenge—severely hinders their widespread deployment in clinical settings. Addressing this limitation, this review focuses on non-fully supervised learning paradigms, systematically investigating the application of semi-supervised, weakly supervised, and unsupervised learning techniques for medical image segmentation. We delve into the theoretical foundations, core advantages, typical application scenarios, and representative algorithmic implementations associated with each paradigm. Furthermore, this paper compiles and critically reviews commonly utilized benchmark datasets within the field. Finally, we discuss future research directions and challenges, offering insights for advancing the field and reducing dependence on extensive annotation.
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spelling doaj-art-91e9a88e77bb43d187d3bc65c4d2911f2025-06-25T13:57:28ZengMDPI AGInformation2078-24892025-05-0116643310.3390/info16060433A Review of Non-Fully Supervised Deep Learning for Medical Image SegmentationXinyue Zhang0Jianfeng Wang1Jinqiao Wei2Xinyu Yuan3Ming Wu4College of Artificial Intelligence, Taiyuan University of Technology, Jinzhong 036000, ChinaSchool of Software, Taiyuan University of Technology, Jinzhong 036000, ChinaSchool of Software, Taiyuan University of Technology, Jinzhong 036000, ChinaSchool of Software, Taiyuan University of Technology, Jinzhong 036000, ChinaDepartment of Computer Science, KU Leuven, 3001 Leuven, BelgiumMedical image segmentation, a critical task in medical image analysis, aims to precisely delineate regions of interest (ROIs) such as organs, lesions, and cells, and is crucial for applications including computer-aided diagnosis, surgical planning, radiation therapy, and pathological analysis. While fully supervised deep learning methods have demonstrated remarkable performance in this domain, their reliance on large-scale, pixel-level annotated datasets—a significant label scarcity challenge—severely hinders their widespread deployment in clinical settings. Addressing this limitation, this review focuses on non-fully supervised learning paradigms, systematically investigating the application of semi-supervised, weakly supervised, and unsupervised learning techniques for medical image segmentation. We delve into the theoretical foundations, core advantages, typical application scenarios, and representative algorithmic implementations associated with each paradigm. Furthermore, this paper compiles and critically reviews commonly utilized benchmark datasets within the field. Finally, we discuss future research directions and challenges, offering insights for advancing the field and reducing dependence on extensive annotation.https://www.mdpi.com/2078-2489/16/6/433medical image segmentationsemi-supervised learningweakly supervised learningunsupervised learningsurvey
spellingShingle Xinyue Zhang
Jianfeng Wang
Jinqiao Wei
Xinyu Yuan
Ming Wu
A Review of Non-Fully Supervised Deep Learning for Medical Image Segmentation
Information
medical image segmentation
semi-supervised learning
weakly supervised learning
unsupervised learning
survey
title A Review of Non-Fully Supervised Deep Learning for Medical Image Segmentation
title_full A Review of Non-Fully Supervised Deep Learning for Medical Image Segmentation
title_fullStr A Review of Non-Fully Supervised Deep Learning for Medical Image Segmentation
title_full_unstemmed A Review of Non-Fully Supervised Deep Learning for Medical Image Segmentation
title_short A Review of Non-Fully Supervised Deep Learning for Medical Image Segmentation
title_sort review of non fully supervised deep learning for medical image segmentation
topic medical image segmentation
semi-supervised learning
weakly supervised learning
unsupervised learning
survey
url https://www.mdpi.com/2078-2489/16/6/433
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