Is Higher BMI Associated with Worse Overall Mortality in Hepatocellular Carcinoma Patients? An Evidence Based Case Report
Background: liver cancer is currently the second deadliest cancer in the world with hepatocelullar carcinoma (HCC) being the commonest form—accounting 90% of all its cases. With the current global alarming increase of obesity, there is hence an increase of fatty liver disease cases, which is one of...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Interna Publishing
2020-02-01
|
| Series: | Acta Medica Indonesiana |
| Subjects: | |
| Online Access: | https://actamedindones.org/index.php/ijim/article/view/956 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839618247032307712 |
|---|---|
| author | Alessa Fahira Ratu Shafira Hanifah Mohamad Prasetio Wardoyo Amirah Deandra Diba Rahadian Ramadhan Julie Dewi Barliana Chyntia Olivia Jasirwan |
| author_facet | Alessa Fahira Ratu Shafira Hanifah Mohamad Prasetio Wardoyo Amirah Deandra Diba Rahadian Ramadhan Julie Dewi Barliana Chyntia Olivia Jasirwan |
| author_sort | Alessa Fahira |
| collection | DOAJ |
| description | Background: liver cancer is currently the second deadliest cancer in the world with hepatocelullar carcinoma (HCC) being the commonest form—accounting 90% of all its cases. With the current global alarming increase of obesity, there is hence an increase of fatty liver disease cases, which is one of the major non-viral etiology of cirrhosis in the world. The objective of this study is to evaluate whether obese HCC patients have worse survival outcome. Methods: PubMed, Cochrane, Scopus, ProQuest, and EBSCOhost were comprehensively searched for systematic review and cohort prognostic researches studying overall survival of HCC patients who are underweight and obesity according to their BMI. Three studies were selected and critically appraised. Data were then summarized descriptively. Results: the three studies included consist of one meta-analysis and two cohort studies. Meta-analysis study stated no association between overweight and obesity status with higher mortality rate in Asian race HCC patients (aHR, 1.10; 95% CI, 0.63-1.92). A cohort study from Japan reported while there was a significant difference of mortality rate in obese HCC patients in bivariate analysis, adjustment with other important prognostic factors with multivariate analysis found no significant correlation between obesity and HCC-related mortality rate (aHR, 1.00; 95% CI, 0.83-1.22). Another cohort study from China reported that HCC-related mortality rate in patients with higher BMI was lower than in patients with lower BMI (aHR, 0.347; 95% CI, 0.239-0.302). Conclusion: there is no association between higher BMI with HCC-related mortality in Asian race patients. |
| format | Article |
| id | doaj-art-8f4dbe99f17e46a4b1f50fb1cc96a7b9 |
| institution | Matheson Library |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2020-02-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-8f4dbe99f17e46a4b1f50fb1cc96a7b92025-07-24T07:01:40ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322020-02-01514349Is Higher BMI Associated with Worse Overall Mortality in Hepatocellular Carcinoma Patients? An Evidence Based Case ReportAlessa Fahira0Ratu Shafira Hanifah1Mohamad Prasetio Wardoyo2Amirah Deandra Diba3Rahadian Ramadhan4Julie Dewi Barliana5Chyntia Olivia Jasirwan6Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaFaculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaFaculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaFaculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaFaculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaDepartment of Ophthalmology, Faculty of Medicine Universitas Indonesia, Jakarta, IndonesiaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, IndonesiaBackground: liver cancer is currently the second deadliest cancer in the world with hepatocelullar carcinoma (HCC) being the commonest form—accounting 90% of all its cases. With the current global alarming increase of obesity, there is hence an increase of fatty liver disease cases, which is one of the major non-viral etiology of cirrhosis in the world. The objective of this study is to evaluate whether obese HCC patients have worse survival outcome. Methods: PubMed, Cochrane, Scopus, ProQuest, and EBSCOhost were comprehensively searched for systematic review and cohort prognostic researches studying overall survival of HCC patients who are underweight and obesity according to their BMI. Three studies were selected and critically appraised. Data were then summarized descriptively. Results: the three studies included consist of one meta-analysis and two cohort studies. Meta-analysis study stated no association between overweight and obesity status with higher mortality rate in Asian race HCC patients (aHR, 1.10; 95% CI, 0.63-1.92). A cohort study from Japan reported while there was a significant difference of mortality rate in obese HCC patients in bivariate analysis, adjustment with other important prognostic factors with multivariate analysis found no significant correlation between obesity and HCC-related mortality rate (aHR, 1.00; 95% CI, 0.83-1.22). Another cohort study from China reported that HCC-related mortality rate in patients with higher BMI was lower than in patients with lower BMI (aHR, 0.347; 95% CI, 0.239-0.302). Conclusion: there is no association between higher BMI with HCC-related mortality in Asian race patients.https://actamedindones.org/index.php/ijim/article/view/956Hepatocelullar carcinomaliver cancermortalitybody mass index (BMI)overweightobesity |
| spellingShingle | Alessa Fahira Ratu Shafira Hanifah Mohamad Prasetio Wardoyo Amirah Deandra Diba Rahadian Ramadhan Julie Dewi Barliana Chyntia Olivia Jasirwan Is Higher BMI Associated with Worse Overall Mortality in Hepatocellular Carcinoma Patients? An Evidence Based Case Report Acta Medica Indonesiana Hepatocelullar carcinoma liver cancer mortality body mass index (BMI) overweight obesity |
| title | Is Higher BMI Associated with Worse Overall Mortality in Hepatocellular Carcinoma Patients? An Evidence Based Case Report |
| title_full | Is Higher BMI Associated with Worse Overall Mortality in Hepatocellular Carcinoma Patients? An Evidence Based Case Report |
| title_fullStr | Is Higher BMI Associated with Worse Overall Mortality in Hepatocellular Carcinoma Patients? An Evidence Based Case Report |
| title_full_unstemmed | Is Higher BMI Associated with Worse Overall Mortality in Hepatocellular Carcinoma Patients? An Evidence Based Case Report |
| title_short | Is Higher BMI Associated with Worse Overall Mortality in Hepatocellular Carcinoma Patients? An Evidence Based Case Report |
| title_sort | is higher bmi associated with worse overall mortality in hepatocellular carcinoma patients an evidence based case report |
| topic | Hepatocelullar carcinoma liver cancer mortality body mass index (BMI) overweight obesity |
| url | https://actamedindones.org/index.php/ijim/article/view/956 |
| work_keys_str_mv | AT alessafahira ishigherbmiassociatedwithworseoverallmortalityinhepatocellularcarcinomapatientsanevidencebasedcasereport AT ratushafirahanifah ishigherbmiassociatedwithworseoverallmortalityinhepatocellularcarcinomapatientsanevidencebasedcasereport AT mohamadprasetiowardoyo ishigherbmiassociatedwithworseoverallmortalityinhepatocellularcarcinomapatientsanevidencebasedcasereport AT amirahdeandradiba ishigherbmiassociatedwithworseoverallmortalityinhepatocellularcarcinomapatientsanevidencebasedcasereport AT rahadianramadhan ishigherbmiassociatedwithworseoverallmortalityinhepatocellularcarcinomapatientsanevidencebasedcasereport AT juliedewibarliana ishigherbmiassociatedwithworseoverallmortalityinhepatocellularcarcinomapatientsanevidencebasedcasereport AT chyntiaoliviajasirwan ishigherbmiassociatedwithworseoverallmortalityinhepatocellularcarcinomapatientsanevidencebasedcasereport |