Oral Administration of 5-Aminolevulinic Acid Does Not Ameliorate Autoimmune Diabetes in NOD Mice

Oral Administration of 5-Aminolevulinic Acid Does Not Ameliorate Autoimmune Diabetes in NOD Mice

<b>Background/Objectives</b>: 5-Aminolevulinic acid (5-ALA) is a biosynthetic precursor of heme that induces heme oxygenase-1 (HO-1). Therapeutic induction of HO-1 has shown effectiveness in various autoimmune disease models, including type 1 diabetes (T1D). However, the efficacy of 5-AL...

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Main Authors: Shinpei Nishikido, Satoru Akazawa, Tetsuro Niri, Shin-Ichi Inoue, Katsuya Matsuda, Taiki Aoshi, Masahiro Nakashima, Ai Haraguchi, Ichiro Horie, Masakazu Kobayashi, Minoru Okita, Atsushi Kawakami, Norio Abiru
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Diabetology
Subjects:
5-aminolevulinic acid
type 1 diabetes
islet autoimmunity
Online Access:https://www.mdpi.com/2673-4540/6/7/62
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