Clinical Efficacy of Mind-Regulating Acupuncture on Post-Stroke Depression Based on the “Microbiota-Gut-Brain Axis” Theory: A Randomized Controlled Study
Jingjun Xie,1 Jinxia Li,2 Qi Sun,1 Jie Jiang1 1Department of Acupuncture, The First People’s Hospital of Huzhou, Huzhou, Zhejiang Province, People’s Republic of China; 2Department of Acupuncture, Huzhou Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang Chinese Medical University, Huzh...
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Dove Medical Press
2025-07-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| author | Xie J Li J Sun Q Jiang J |
| author_facet | Xie J Li J Sun Q Jiang J |
| author_sort | Xie J |
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| description | Jingjun Xie,1 Jinxia Li,2 Qi Sun,1 Jie Jiang1 1Department of Acupuncture, The First People’s Hospital of Huzhou, Huzhou, Zhejiang Province, People’s Republic of China; 2Department of Acupuncture, Huzhou Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang Chinese Medical University, Huzhou, Zhejiang Province, People’s Republic of ChinaCorrespondence: Jie Jiang, Department of Acupuncture, The First People’s Hospital of Huzhou, No. 158, Guang Chang Hou Road, Huzhou, Zhejiang Province, 313000, People’s Republic of China, Email jairjiang@163.comObjective: This study explored the clinical efficacy and mechanisms of Mind-Regulating Acupuncture (MRA) for post-stroke depression (PSD) based on the “microbiota-gut-brain axis” theory.Methods: 92 PSD patients were randomly divided into an observation group (received conventional therapy + MRA) and a control group (conventional therapy only). After 8 weeks of treatment, multiple indicators including depression scores, neurological function scores, and levels of neurotransmitters and gut microbiota were compared.Results: MRA significantly improved depressive symptoms, neurological function, and daily living abilities in PSD patients. It increased serum 5-HT and BDNF levels, and regulated gut microbiota, promoting beneficial bacteria and reducing harmful ones.Conclusion: MRA effectively treats PSD, and its mechanism may involve regulating the “microbiota-gut-brain axis”, increasing beneficial gut bacteria, and enhancing 5-HT and BDNF levels.Keywords: post-stroke depression, mind-regulating acupuncture, microbiota-gut-brain axis, gut microbiota |
| format | Article |
| id | doaj-art-8ee1a454b75e4e14adc59e09a1723e1c |
| institution | Matheson Library |
| issn | 1178-2021 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj-art-8ee1a454b75e4e14adc59e09a1723e1c2025-07-10T17:45:47ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212025-07-01Volume 21Issue 113491358104562Clinical Efficacy of Mind-Regulating Acupuncture on Post-Stroke Depression Based on the “Microbiota-Gut-Brain Axis” Theory: A Randomized Controlled StudyXie J0Li J1Sun Q2Jiang J3Department of AcupunctureAcupuncture DepartmentDepartment of rehabilitation medicineDepartment of rehabilitation medicineJingjun Xie,1 Jinxia Li,2 Qi Sun,1 Jie Jiang1 1Department of Acupuncture, The First People’s Hospital of Huzhou, Huzhou, Zhejiang Province, People’s Republic of China; 2Department of Acupuncture, Huzhou Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang Chinese Medical University, Huzhou, Zhejiang Province, People’s Republic of ChinaCorrespondence: Jie Jiang, Department of Acupuncture, The First People’s Hospital of Huzhou, No. 158, Guang Chang Hou Road, Huzhou, Zhejiang Province, 313000, People’s Republic of China, Email jairjiang@163.comObjective: This study explored the clinical efficacy and mechanisms of Mind-Regulating Acupuncture (MRA) for post-stroke depression (PSD) based on the “microbiota-gut-brain axis” theory.Methods: 92 PSD patients were randomly divided into an observation group (received conventional therapy + MRA) and a control group (conventional therapy only). After 8 weeks of treatment, multiple indicators including depression scores, neurological function scores, and levels of neurotransmitters and gut microbiota were compared.Results: MRA significantly improved depressive symptoms, neurological function, and daily living abilities in PSD patients. It increased serum 5-HT and BDNF levels, and regulated gut microbiota, promoting beneficial bacteria and reducing harmful ones.Conclusion: MRA effectively treats PSD, and its mechanism may involve regulating the “microbiota-gut-brain axis”, increasing beneficial gut bacteria, and enhancing 5-HT and BDNF levels.Keywords: post-stroke depression, mind-regulating acupuncture, microbiota-gut-brain axis, gut microbiotahttps://www.dovepress.com/clinical-efficacy-of-mind-regulating-acupuncture-on-post-stroke-depres-peer-reviewed-fulltext-article-NDTPost-stroke depressionMind-Regulating AcupunctureMicrobiota-Gut-Brain AxisGut microbiota |
| spellingShingle | Xie J Li J Sun Q Jiang J Clinical Efficacy of Mind-Regulating Acupuncture on Post-Stroke Depression Based on the “Microbiota-Gut-Brain Axis” Theory: A Randomized Controlled Study Neuropsychiatric Disease and Treatment Post-stroke depression Mind-Regulating Acupuncture Microbiota-Gut-Brain Axis Gut microbiota |
| title | Clinical Efficacy of Mind-Regulating Acupuncture on Post-Stroke Depression Based on the “Microbiota-Gut-Brain Axis” Theory: A Randomized Controlled Study |
| title_full | Clinical Efficacy of Mind-Regulating Acupuncture on Post-Stroke Depression Based on the “Microbiota-Gut-Brain Axis” Theory: A Randomized Controlled Study |
| title_fullStr | Clinical Efficacy of Mind-Regulating Acupuncture on Post-Stroke Depression Based on the “Microbiota-Gut-Brain Axis” Theory: A Randomized Controlled Study |
| title_full_unstemmed | Clinical Efficacy of Mind-Regulating Acupuncture on Post-Stroke Depression Based on the “Microbiota-Gut-Brain Axis” Theory: A Randomized Controlled Study |
| title_short | Clinical Efficacy of Mind-Regulating Acupuncture on Post-Stroke Depression Based on the “Microbiota-Gut-Brain Axis” Theory: A Randomized Controlled Study |
| title_sort | clinical efficacy of mind regulating acupuncture on post stroke depression based on the amp ldquo microbiota gut brain axis amp rdquo theory a randomized controlled study |
| topic | Post-stroke depression Mind-Regulating Acupuncture Microbiota-Gut-Brain Axis Gut microbiota |
| url | https://www.dovepress.com/clinical-efficacy-of-mind-regulating-acupuncture-on-post-stroke-depres-peer-reviewed-fulltext-article-NDT |
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