STAT3-mediated polarization of A2 phenotype astrocytes alleviates painful diabetic peripheral neuropathy in type 1 diabetic rats

STAT3-mediated polarization of A2 phenotype astrocytes alleviates painful diabetic peripheral neuropathy in type 1 diabetic rats

Objective To study the effect of STAT3 over-expression-mediated A2 astrocyte polarization on type 1 diabetic mellitus(T1DM)peripheral neuropathy. Methods STAT3 over-expression virus was intrathecally injected into type 1 diabetic rats with painful diabetic neuropathy(PDN). The rats were divided into...

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Bibliographic Details
Main Author: FAN Tingting, LI Huili, GUO Ruijuan, MA Danxu, WANG Yun
Format: Article
Language:Chinese
Published: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2025-07-01
Series:Jichu yixue yu linchuang
Subjects:
type 1 diabetic mellitus (t1dm)|painful diabetic neuropathy (pdn)|signal transducer and activator of transcription 3 (stat3)|a2 phenotype reactive astrocytes
Online Access:https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-7-889.pdf
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