Digitoflavone Ameliorates Acute Lung Injury via Disturbing the Formation of Functional Stimulator of Interferon Genes Signalosome

QR Code

Digitoflavone Ameliorates Acute Lung Injury via Disturbing the Formation of Functional Stimulator of Interferon Genes Signalosome

Objective: The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon (IFN) genes (STING) signaling pathway has been implicated in the initiation and maintenance of a variety of inflammatory diseases. Thus, the search for modulators of the cGAS-STING signaling pathway is likely to contribute to the...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jun-Jie Li, Qing Yao, Ming Dong, Yan Wang, Ye Xiu, Zhi-Xin Wu, Xiao-Mei Zhao, Yin-Kang Wang, Xian-Ling Wang, Yu-Xuan Tian, Xiao-He Xiao, Zhao-Fang Bai
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2025-04-01
Series:	World Journal of Traditional Chinese Medicine
Subjects:	acute lung injury cyclic gmp-amp synthase-stimulator of interferon genes digitoflavone interferon regulatory factor 3 stimulator of interferon genes signalosome type i interferon
Online Access:	https://journals.lww.com/10.4103/wjtcm.wjtcm_100_24
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The expression of interferon-stimulated genes (interferon “signature”) in patients with rheumatoid arthritis (Preliminary results)
by: A. S. Avdeeva, et al.
Published: (2021-01-01)

Editorial: Modulation of pro-inflammatory signaling by interferons
by: René Huber, et al.
Published: (2025-07-01)

Expression of interferon-stimulated genes in patients with rheumatoid arthritis on anti-B-cell therapy (preliminary results)
by: A. S. Avdeeva, et al.
Published: (2021-10-01)

Interferons : an example of communication /
by: Sanders, F. Kingsley (Frank Kingsley)
Published: (1981)

Interferon status at the women with recurrent genital herpes in combined liposomal RNA treatment
by: A. Sh. Makhmutkhodzhayev, et al.
Published: (2012-06-01)

The effectiveness of Interferon-Ophthalmo, an antiviral and immunotropic drug, in the treatment of adenoviral ophthalmic infections
by: E. V. Yani, et al.
Published: (2023-03-01)

Clinical significance of interferon status in patients with systemic lupus erythematosus. Preliminary data
by: T. A. Panafidina, et al.
Published: (2025-03-01)

Progress in the development and use of antiviral drugs and interferon: report of a WHO Scientific Group /
by: WHO Scientific Group
Published: (1987)

ACTIVATION OF SYNTHESIS OF ENDOGENOUS INTERFERON (REVIEW)
by: V. V. Poloskov, et al.
Published: (2019-01-01)

ADMINISTRATION CRITERIA FOR INTERFERON-BASED DRUGS AND ITS INDUCERS IN ACUTE RESPIRATORY INFECTIONS IN CHILDREN
by: E. G. Golovacheva, et al.
Published: (2014-07-01)

Association of interferon regulatory factor 8 dysregulation with dry eye in Sjögren’s syndrome
by: Jiao Wang, et al.
Published: (2025-08-01)

The role of cytokines and interferons during pregnancy
by: T. Е. Belokrinitskaya, et al.
Published: (2024-09-01)

DNA Methylation Patterns of Interferon Gamma Gene Promoter and Serum Level in Pulmonary Tuberculosis: Their Role in Prognosis
by: Zayr et al.
Published: (2019-03-01)

Portrait of a patient with systemic lupus erythematosus for the prescription of the type I interferon inhibitor anifrolumab
by: T. M. Reshetnyak, et al.
Published: (2023-12-01)

EFFICACY OF INTRAPERITONEAL INTERFERON-α ADMINISTRATION FOR TREATMENT OF ENDOMETRIOSIS IN RATS
by: R. V. Pavlov, et al.
Published: (2014-07-01)

Efficacy and safety of the type I interferon receptor inhibitor anifrolumab in patients with systemic lupus erythematosus (results of a 6-month study)
by: T. M. Reshetnyak, et al.
Published: (2024-04-01)

Rapid achievement of low disease activity during the use of a type I interferon inhibitor in a patient with torpid systemic lupus erythematosus (case report)
by: A. A. Baranov, et al.
Published: (2024-06-01)

ALLELIC POLYMORPHISM OF IFNγ GENE IN PATIENTS WITH PULMONARY TUBERCULOSIS
by: E. L. Nikulina, et al.
Published: (2014-07-01)

Interferons lambda – therapeutic application
by: N. A. Kikhtenko, et al.
Published: (2020-05-01)

Results of using interferon α-2b in combination with vitamins E and C in the treatment of urogenital infections in pregnant women
by: T. A. Ruzhentsova, et al.
Published: (2021-06-01)

Viral Strategies and Cellular Countermeasures That Regulate mRNA Access to the Translation Apparatus
by: Christopher U. T. Hellen
Published: (2025-05-01)

Evaluation of the effectiveness and safety of interferon alpha-2b ointment and gel for prevention of acute respiratory infections in organized groups
by: K. V. Kozlov, et al.
Published: (2024-04-01)

ROLE OF INTERFERONS IN REGULATION OF OSTOGENIC AND OSTEORESORPTIVE PROCESSES
by: L. A. Dmitrieva, et al.
Published: (2012-09-01)

Kartogenin‐Loaded Aminated Hollow Mesoporous Prussian Blue Nanozyme‐Reinforced Hydrogel Remodels the Senescent Microenvironment via Reactive Oxygen Species Scavenging and Stimulator of Interferon Genes Inhibition to Promote Cartilage Regeneration
by: Shu‐Hang He, et al.
Published: (2025-07-01)

Keratopathy in Patients with Adenoviral Keratoconjunctivitis: Evaluation of the Effectiveness of Modern Interferon Preparations
by: E. A. Drozdova, et al.
Published: (2023-04-01)

IMMUNOINFLAMMATORY RHEUMATIC DISEASES ASSOCIATED WITH TYPE I INTERFERON: NEW EVIDENCE
by: E. L. Nasonov, et al.
Published: (2019-09-01)

New approaches to the therapy of infectious mononucleosis
by: Yu. G. Pritulina, et al.
Published: (2021-06-01)

Interferons alpha and gamma, pidotimod, and tilorone in the treatment of acute respiratory infections in patients with allergic rhinitis: a prospective, cohort clinical and immunological study
by: O. V. Kalyuzhin, et al.
Published: (2022-07-01)

Stimulator of Interferon Genes (STING)-Type I Interferon Signaling: Bridging Immunity and Pain
by: Ti-Chuan Chiu, et al.
Published: (2025-06-01)

Effect of interferon on broilers' fecal microbiome composition
by: Inna Burakova, et al.
Published: (2025-04-01)

Interferon-γ: biological function and application for study of cellular immune response
by: A. A. Lutckii, et al.
Published: (2016-02-01)

Investigation of Cytotoxic Effects of Recombinant Human Interferon Lambda-1 and Its Pegylated Form on Human Conjunctival Epithelial Cells
by: N. A. Kikhtenko, et al.
Published: (2021-12-01)

PREVALENCE OF SIDE EFFECTS OF INTERFERON THERAPY IN CHILDREN WITH CHRONIC VIRAL HEPATITIS C
by: T. A. Skvortsova, et al.
Published: (2013-05-01)

Florfenicol can inhibit chick growth and lead to immunosuppression
by: Fanliang Meng, et al.
Published: (2025-01-01)

Interferon system in patients with rheumatoid arthritis infected with hepatitis В and С viruses
by: R M Balabanova, et al.
Published: (2003-08-01)

A Novel Microencapsulated Bovine Recombinant Interferon Tau Formulation for Luteolysis Modulation in Cattle
by: Emilio Lamazares, et al.
Published: (2025-07-01)

Interferon system in typical chronic and atypically occurring chronic active herpes virus infections
by: E. O. Khalturina, et al.
Published: (2023-12-01)

Investigation of the antiviral activity of the recombinant human interferon lambda 1 in human conjunctiva cell culture
by: N. A. Kikhtenko, et al.
Published: (2021-10-01)

Efficacy of differentiated targeted interferon and immunomodulatory therapy focused on pathological immunophenotypes in patients with atypical chronic active herpesvirus infections
by: I. V. Nesterova, et al.
Published: (2024-03-01)

Features of the functioning of the innate and adaptive immunity system in patients with COVID-19 of the older age group
by: O. N. Scheglovitova, et al.
Published: (2023-10-01)