The role of monitoring the level of matrix metalloproteinase 3 in patients with rheumatoid arthritis on anti-B-cell therapy
Objective: to evaluate the role of monitoring the level of matrix metalloproteinase 3 (MMP-3) in patients with rheumatoid arthritis (RA) during anti-B-cell therapy.Material and methods. The study included 54 patients with a reliable diagnosis of RA. Depending on the therapy, all patients were divide...
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| author | A. S. Avdeeva V. V. Rybakova O. G. Alekseeva E. L. Nasonov |
| author_facet | A. S. Avdeeva V. V. Rybakova O. G. Alekseeva E. L. Nasonov |
| author_sort | A. S. Avdeeva |
| collection | DOAJ |
| description | Objective: to evaluate the role of monitoring the level of matrix metalloproteinase 3 (MMP-3) in patients with rheumatoid arthritis (RA) during anti-B-cell therapy.Material and methods. The study included 54 patients with a reliable diagnosis of RA. Depending on the therapy, all patients were divided into two groups: 34 patients received the original RTM (group 1) and 20 patients – biosimilar (group 2) in a total dose of 1200 mg according to the standard scheme. The concentration of MMP-3 in serum was measured by enzyme immunoassay using a kit of reagents from Invitrogen (USA).Results. The level of MMP-3 in patients with RA was significantly higher than in healthy donors, its median was 42.9 [10.0; 110.7] and 7.8 [5.5; 11.8] ng/ml, respectively (p<0.05). 12 and 24 weeks after the first infusion of the original RTM, there was a statistically significant decrease in the concentration of MMP-3, amounting to 80% of the initial level. Against the background of the use of the RTM biosimilar, after 12 and 24 weeks, a statistically significant decrease in the concentration of MMP-3 was observed, which was 46.8 and 59% of the basal level, respectively. According to the ROC analysis, it was found that the basal level of IL-6 more than 100.0 pg/ ml and the level of MMP-3 more than 78.6 ng/ml were associated with the preservation of inflammatory activity by the 24th week of therapy with the RTM biosimilar with a sensitivity of 85% and 57% and a specificity of 62% and 61.5%, respectively. Conclusion. Determining the level of MMP-3 in patients receiving anti-B-cell therapy is important for a more objective assessment of disease activity and predicting the effectiveness of treatment. Key words: rheumatoid arthritis, matrix metalloproteinase 3, anti-B-cell therapy, rituximab biosimilar>˂ 0.05). 12 and 24 weeks after the first infusion of the original RTM, there was a statistically significant decrease in the concentration of MMP-3, amounting to 80% of the initial level. Against the background of the use of the RTM biosimilar, after 12 and 24 weeks, a statistically significant decrease in the concentration of MMP-3 was observed, which was 46.8 and 59% of the basal level, respectively. According to the ROC analysis, it was found that the basal level of IL-6 more than 100.0 pg/ ml and the level of MMP-3 more than 78.6 ng/ml were associated with the preservation of inflammatory activity by the 24th week of therapy with the RTM biosimilar with a sensitivity of 85% and 57% and a specificity of 62% and 61.5%, respectively.Conclusion. Determining the level of MMP-3 in patients receiving anti-B-cell therapy is important for a more objective assessment of disease activity and predicting the effectiveness of treatment. |
| format | Article |
| id | doaj-art-8dbf835b08b94e68a95fe42b1d76de8a |
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| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2022-09-01 |
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| spelling | doaj-art-8dbf835b08b94e68a95fe42b1d76de8a2025-08-04T17:04:02ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922022-09-0160447348010.47360/1995-4484-2022-473-4802833The role of monitoring the level of matrix metalloproteinase 3 in patients with rheumatoid arthritis on anti-B-cell therapyA. S. Avdeeva0V. V. Rybakova1O. G. Alekseeva2E. L. Nasonov3V.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University)Objective: to evaluate the role of monitoring the level of matrix metalloproteinase 3 (MMP-3) in patients with rheumatoid arthritis (RA) during anti-B-cell therapy.Material and methods. The study included 54 patients with a reliable diagnosis of RA. Depending on the therapy, all patients were divided into two groups: 34 patients received the original RTM (group 1) and 20 patients – biosimilar (group 2) in a total dose of 1200 mg according to the standard scheme. The concentration of MMP-3 in serum was measured by enzyme immunoassay using a kit of reagents from Invitrogen (USA).Results. The level of MMP-3 in patients with RA was significantly higher than in healthy donors, its median was 42.9 [10.0; 110.7] and 7.8 [5.5; 11.8] ng/ml, respectively (p<0.05). 12 and 24 weeks after the first infusion of the original RTM, there was a statistically significant decrease in the concentration of MMP-3, amounting to 80% of the initial level. Against the background of the use of the RTM biosimilar, after 12 and 24 weeks, a statistically significant decrease in the concentration of MMP-3 was observed, which was 46.8 and 59% of the basal level, respectively. According to the ROC analysis, it was found that the basal level of IL-6 more than 100.0 pg/ ml and the level of MMP-3 more than 78.6 ng/ml were associated with the preservation of inflammatory activity by the 24th week of therapy with the RTM biosimilar with a sensitivity of 85% and 57% and a specificity of 62% and 61.5%, respectively. Conclusion. Determining the level of MMP-3 in patients receiving anti-B-cell therapy is important for a more objective assessment of disease activity and predicting the effectiveness of treatment. Key words: rheumatoid arthritis, matrix metalloproteinase 3, anti-B-cell therapy, rituximab biosimilar>˂ 0.05). 12 and 24 weeks after the first infusion of the original RTM, there was a statistically significant decrease in the concentration of MMP-3, amounting to 80% of the initial level. Against the background of the use of the RTM biosimilar, after 12 and 24 weeks, a statistically significant decrease in the concentration of MMP-3 was observed, which was 46.8 and 59% of the basal level, respectively. According to the ROC analysis, it was found that the basal level of IL-6 more than 100.0 pg/ ml and the level of MMP-3 more than 78.6 ng/ml were associated with the preservation of inflammatory activity by the 24th week of therapy with the RTM biosimilar with a sensitivity of 85% and 57% and a specificity of 62% and 61.5%, respectively.Conclusion. Determining the level of MMP-3 in patients receiving anti-B-cell therapy is important for a more objective assessment of disease activity and predicting the effectiveness of treatment.https://rsp.mediar-press.net/rsp/article/view/3202rheumatoid arthritismatrix metalloproteinase 3anti-b-cell therapyrituximab biosimilar |
| spellingShingle | A. S. Avdeeva V. V. Rybakova O. G. Alekseeva E. L. Nasonov The role of monitoring the level of matrix metalloproteinase 3 in patients with rheumatoid arthritis on anti-B-cell therapy Научно-практическая ревматология rheumatoid arthritis matrix metalloproteinase 3 anti-b-cell therapy rituximab biosimilar |
| title | The role of monitoring the level of matrix metalloproteinase 3 in patients with rheumatoid arthritis on anti-B-cell therapy |
| title_full | The role of monitoring the level of matrix metalloproteinase 3 in patients with rheumatoid arthritis on anti-B-cell therapy |
| title_fullStr | The role of monitoring the level of matrix metalloproteinase 3 in patients with rheumatoid arthritis on anti-B-cell therapy |
| title_full_unstemmed | The role of monitoring the level of matrix metalloproteinase 3 in patients with rheumatoid arthritis on anti-B-cell therapy |
| title_short | The role of monitoring the level of matrix metalloproteinase 3 in patients with rheumatoid arthritis on anti-B-cell therapy |
| title_sort | role of monitoring the level of matrix metalloproteinase 3 in patients with rheumatoid arthritis on anti b cell therapy |
| topic | rheumatoid arthritis matrix metalloproteinase 3 anti-b-cell therapy rituximab biosimilar |
| url | https://rsp.mediar-press.net/rsp/article/view/3202 |
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