MULTIPLE ORGAN FAILURE IN PEDIATRIC CRITICAL CARE: ADVANCES IN PATHOPHYSIOLOGY AND PROGNOSIS
Multiple organ failure is a leading cause of admission to the intensive care units, characterized by a high case fatality rate and significant financial costs. Here we review the mechanisms of multiple organ failure in pediatric patients (triggers, concomitant diseases, release of danger- and pathog...
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| Format: | Article |
| Language: | Russian |
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Kemerovo State Medical University
2017-09-01
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| Series: | Фундаментальная и клиническая медицина |
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| Online Access: | https://fcm.kemsmu.ru/jour/article/view/62 |
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| author | EVGENIYA O. Petrova EVGENIY V. Grigoriev |
| author_facet | EVGENIYA O. Petrova EVGENIY V. Grigoriev |
| author_sort | EVGENIYA O. Petrova |
| collection | DOAJ |
| description | Multiple organ failure is a leading cause of admission to the intensive care units, characterized by a high case fatality rate and significant financial costs. Here we review the mechanisms of multiple organ failure in pediatric patients (triggers, concomitant diseases, release of danger- and pathogen-associated molecular patterns, bacterial translocation, epithelial, endothelial, or mitochondrial dysfunction, and inadequate immune response) and recent diagnostic and prognostic scales. |
| format | Article |
| id | doaj-art-8d147c9e891b42f1bfbe9eb4b4266c6c |
| institution | Matheson Library |
| issn | 2500-0764 2542-0941 |
| language | Russian |
| publishDate | 2017-09-01 |
| publisher | Kemerovo State Medical University |
| record_format | Article |
| series | Фундаментальная и клиническая медицина |
| spelling | doaj-art-8d147c9e891b42f1bfbe9eb4b4266c6c2025-08-03T12:59:23ZrusKemerovo State Medical UniversityФундаментальная и клиническая медицина2500-07642542-09412017-09-0123828761MULTIPLE ORGAN FAILURE IN PEDIATRIC CRITICAL CARE: ADVANCES IN PATHOPHYSIOLOGY AND PROGNOSISEVGENIYA O. Petrova0EVGENIY V. Grigoriev1Kemerovo State Medical UniversityResearch Institute for Complex Issues of Cardiovascular DiseasesMultiple organ failure is a leading cause of admission to the intensive care units, characterized by a high case fatality rate and significant financial costs. Here we review the mechanisms of multiple organ failure in pediatric patients (triggers, concomitant diseases, release of danger- and pathogen-associated molecular patterns, bacterial translocation, epithelial, endothelial, or mitochondrial dysfunction, and inadequate immune response) and recent diagnostic and prognostic scales.https://fcm.kemsmu.ru/jour/article/view/62детиполиорганная недостаточностьсистемный воспалительный ответпатофизиологияпрогнозchildrenmultiple organ failuresystemic inflammatory responsepathophysiologyprognosis |
| spellingShingle | EVGENIYA O. Petrova EVGENIY V. Grigoriev MULTIPLE ORGAN FAILURE IN PEDIATRIC CRITICAL CARE: ADVANCES IN PATHOPHYSIOLOGY AND PROGNOSIS Фундаментальная и клиническая медицина дети полиорганная недостаточность системный воспалительный ответ патофизиология прогноз children multiple organ failure systemic inflammatory response pathophysiology prognosis |
| title | MULTIPLE ORGAN FAILURE IN PEDIATRIC CRITICAL CARE: ADVANCES IN PATHOPHYSIOLOGY AND PROGNOSIS |
| title_full | MULTIPLE ORGAN FAILURE IN PEDIATRIC CRITICAL CARE: ADVANCES IN PATHOPHYSIOLOGY AND PROGNOSIS |
| title_fullStr | MULTIPLE ORGAN FAILURE IN PEDIATRIC CRITICAL CARE: ADVANCES IN PATHOPHYSIOLOGY AND PROGNOSIS |
| title_full_unstemmed | MULTIPLE ORGAN FAILURE IN PEDIATRIC CRITICAL CARE: ADVANCES IN PATHOPHYSIOLOGY AND PROGNOSIS |
| title_short | MULTIPLE ORGAN FAILURE IN PEDIATRIC CRITICAL CARE: ADVANCES IN PATHOPHYSIOLOGY AND PROGNOSIS |
| title_sort | multiple organ failure in pediatric critical care advances in pathophysiology and prognosis |
| topic | дети полиорганная недостаточность системный воспалительный ответ патофизиология прогноз children multiple organ failure systemic inflammatory response pathophysiology prognosis |
| url | https://fcm.kemsmu.ru/jour/article/view/62 |
| work_keys_str_mv | AT evgeniyaopetrova multipleorganfailureinpediatriccriticalcareadvancesinpathophysiologyandprognosis AT evgeniyvgrigoriev multipleorganfailureinpediatriccriticalcareadvancesinpathophysiologyandprognosis |