Growing intradiploic epidermoid cyst presenting as a diagnostic challenge in the setting of Langerhans cell histiocytosis: A case report
Epidermoid cysts (EC) are benign cystic lesions lined by squamous epithelium resulting from entrapped ectodermal elements during development. These can occur in various anatomic locations, including intracranial, intradiploic, spinal and in the superficial soft tissues. Although benign, these can gr...
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Elsevier
2025-09-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043325004765 |
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| author | Benjamin S. Fletcher, MD Benjamin A. Johnson-Tesch, MD John C. Benson, MD Alex A. Nagelschneider, MD Lisa M. Marinelli, MD Dong Kun Kim, MD |
| author_facet | Benjamin S. Fletcher, MD Benjamin A. Johnson-Tesch, MD John C. Benson, MD Alex A. Nagelschneider, MD Lisa M. Marinelli, MD Dong Kun Kim, MD |
| author_sort | Benjamin S. Fletcher, MD |
| collection | DOAJ |
| description | Epidermoid cysts (EC) are benign cystic lesions lined by squamous epithelium resulting from entrapped ectodermal elements during development. These can occur in various anatomic locations, including intracranial, intradiploic, spinal and in the superficial soft tissues. Although benign, these can grow or rupture, and mimic malignant tumor or infection. Here, we describe the case of an 8-month-old male with cutaneous Langerhans cell histiocytosis (LCH) presenting with a lytic calvarial lesion initially thought to be osseous involvement of LCH. Further workup revealed imaging findings discordant with this diagnosis and instead suggestive of an intradiploic EC which was subsequently confirmed with pathology. This case illustrates the importance of keeping the differential diagnosis broad and re-evaluating the diagnosis based on the imaging appearance despite the presumptive diagnosis provided clinically. |
| format | Article |
| id | doaj-art-8cdbb5f8aa2443e8b5a3a5b1841fbb4b |
| institution | Matheson Library |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-8cdbb5f8aa2443e8b5a3a5b1841fbb4b2025-07-13T04:53:52ZengElsevierRadiology Case Reports1930-04332025-09-0120943854389Growing intradiploic epidermoid cyst presenting as a diagnostic challenge in the setting of Langerhans cell histiocytosis: A case reportBenjamin S. Fletcher, MD0Benjamin A. Johnson-Tesch, MD1John C. Benson, MD2Alex A. Nagelschneider, MD3Lisa M. Marinelli, MD4Dong Kun Kim, MD5Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA; Corresponding author.Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USADepartment of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USADepartment of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USADepartment of Pathology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA; Department of Dermatology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USADepartment of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USAEpidermoid cysts (EC) are benign cystic lesions lined by squamous epithelium resulting from entrapped ectodermal elements during development. These can occur in various anatomic locations, including intracranial, intradiploic, spinal and in the superficial soft tissues. Although benign, these can grow or rupture, and mimic malignant tumor or infection. Here, we describe the case of an 8-month-old male with cutaneous Langerhans cell histiocytosis (LCH) presenting with a lytic calvarial lesion initially thought to be osseous involvement of LCH. Further workup revealed imaging findings discordant with this diagnosis and instead suggestive of an intradiploic EC which was subsequently confirmed with pathology. This case illustrates the importance of keeping the differential diagnosis broad and re-evaluating the diagnosis based on the imaging appearance despite the presumptive diagnosis provided clinically.http://www.sciencedirect.com/science/article/pii/S1930043325004765Epidermoid cystIntradiploicLangerhans cell histiocytosisLytic lesionCalvarium |
| spellingShingle | Benjamin S. Fletcher, MD Benjamin A. Johnson-Tesch, MD John C. Benson, MD Alex A. Nagelschneider, MD Lisa M. Marinelli, MD Dong Kun Kim, MD Growing intradiploic epidermoid cyst presenting as a diagnostic challenge in the setting of Langerhans cell histiocytosis: A case report Radiology Case Reports Epidermoid cyst Intradiploic Langerhans cell histiocytosis Lytic lesion Calvarium |
| title | Growing intradiploic epidermoid cyst presenting as a diagnostic challenge in the setting of Langerhans cell histiocytosis: A case report |
| title_full | Growing intradiploic epidermoid cyst presenting as a diagnostic challenge in the setting of Langerhans cell histiocytosis: A case report |
| title_fullStr | Growing intradiploic epidermoid cyst presenting as a diagnostic challenge in the setting of Langerhans cell histiocytosis: A case report |
| title_full_unstemmed | Growing intradiploic epidermoid cyst presenting as a diagnostic challenge in the setting of Langerhans cell histiocytosis: A case report |
| title_short | Growing intradiploic epidermoid cyst presenting as a diagnostic challenge in the setting of Langerhans cell histiocytosis: A case report |
| title_sort | growing intradiploic epidermoid cyst presenting as a diagnostic challenge in the setting of langerhans cell histiocytosis a case report |
| topic | Epidermoid cyst Intradiploic Langerhans cell histiocytosis Lytic lesion Calvarium |
| url | http://www.sciencedirect.com/science/article/pii/S1930043325004765 |
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