Targeting the KLF5/PI3K/AKT axis as a therapeutic strategy to overcome neoadjuvant chemoresistance in colorectal cancer

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Targeting the KLF5/PI3K/AKT axis as a therapeutic strategy to overcome neoadjuvant chemoresistance in colorectal cancer

BackgroundOxaliplatin-based neoadjuvant chemotherapy (NAC) is the standard treatment for advanced colorectal cancer (CRC), yet resistance to NAC poses a significant clinical challenge.MethodsTo investigate the mechanisms of chemoresistance, we analyzed single-cell RNA sequencing (scRNA-seq) data fro...

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Bibliographic Details
Main Authors:	Meiling Gao, Jiahao Qian, Ping Xia, Wancheng Liu, Yunjia Jiang, Yuchang Xia, Xin Yao, Qingqing Jiao, Minggang Wei
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Immunology
Subjects:	colorectal cancer oxaliplatin resistance KLF5 GDC-0941 neoadjuvant chemotherapy PI3K/Akt pathway
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593639/full
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