COMPONENTS OF THE METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS WITH DIFFERENT LEVELS OF VITAMIN D: A CROSS-SECTIONAL STUDY
Background. Vitamin D is a significant risk factor for atherogenic disorders. It is of interest to study the relationship between vitamin D deficiency and the components of the metabolic syndrome, insulin resistance and markers of chronic inflammation in different age groups.Objective. Our aim was...
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"Paediatrician" Publishers LLC
2017-07-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/1757 |
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| author | Svetlana I. Malyavskaya Аndrej V. Lebedev Galina N. Kostrova |
| author_facet | Svetlana I. Malyavskaya Аndrej V. Lebedev Galina N. Kostrova |
| author_sort | Svetlana I. Malyavskaya |
| collection | DOAJ |
| description | Background. Vitamin D is a significant risk factor for atherogenic disorders. It is of interest to study the relationship between vitamin D deficiency and the components of the metabolic syndrome, insulin resistance and markers of chronic inflammation in different age groups.Objective. Our aim was to study association of the components of the metabolic syndrome and pro-atherogenic metabolic disorders with vitamin D levels in children and adolescents.Methods. In a cross-sectional (one-stage) study, the serum 25(OH)D level in children and adolescents was determined. The relationship between the 25(ОН)D level and the presence of the metabolic syndrome was assessed in quartile groups.Results. The study included 319 children and adolescents (49% — girls) aged 10–15 years. In the quartile I in terms of the 25(ОН)D level, higher (as compared with the quartile IV) mean level values of insulin (11.5 ± 6.3 and 7.3 ± 4.0 mmol/L, p <0.001), HOMA index (2.4 ± 0.8 and 1.6 ± 0.7, p <0.001), body mass index (22.6 ± 4.3 and 19.3 ± 3.9 kg/m2, p = 0.012), waist circumference (68 ± 11 and 61 ± 12 cm, p = 0.034), blood concentration of C-reactive protein (2.3 ± 1 and 0.9 ± 0.7 mg/ml, p <0.001), diastolic blood pressure (70 ± 7 and 65 ± 6 mm Hg, р = 0.028), uric acid (0.29 ± 0.06 and 0.21 ± 0.06 mmol/L, р = 0.021), glucose (4.8 ± 0.6 and 4.6 ± 0.6 mmol/L, p = 0.011), triglycerides (0.86 ± 0.37 and 0.72 ± 0.31 mmol/L, р = 0.017), and lower mean level values of highdensity lipoprotein cholesterol (1.38 ± 0.36 and 1.58 ± 0.31 mmol/L, p = 0.011) were noted. Multivariate regression analysis showed an independent relationship between the 25(ОН)D level, C-reactive protein level (β = -0.55, p <0.001), and HOMA index (β = -0.96, p < 0.001).Conclusion. A low vitamin D level in the blood serum in children is associated with the components of the metabolic syndrome. |
| format | Article |
| id | doaj-art-8bb512e35a9e47b5b7cea79da61ce56c |
| institution | Matheson Library |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2017-07-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-8bb512e35a9e47b5b7cea79da61ce56c2025-08-04T13:09:38Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352017-07-0116321321910.15690/vsp.v16i3.17311683COMPONENTS OF THE METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS WITH DIFFERENT LEVELS OF VITAMIN D: A CROSS-SECTIONAL STUDYSvetlana I. Malyavskaya0Аndrej V. Lebedev1Galina N. Kostrova2Northern State Medical UniversityNorthern State Medical UniversityNorthern State Medical UniversityBackground. Vitamin D is a significant risk factor for atherogenic disorders. It is of interest to study the relationship between vitamin D deficiency and the components of the metabolic syndrome, insulin resistance and markers of chronic inflammation in different age groups.Objective. Our aim was to study association of the components of the metabolic syndrome and pro-atherogenic metabolic disorders with vitamin D levels in children and adolescents.Methods. In a cross-sectional (one-stage) study, the serum 25(OH)D level in children and adolescents was determined. The relationship between the 25(ОН)D level and the presence of the metabolic syndrome was assessed in quartile groups.Results. The study included 319 children and adolescents (49% — girls) aged 10–15 years. In the quartile I in terms of the 25(ОН)D level, higher (as compared with the quartile IV) mean level values of insulin (11.5 ± 6.3 and 7.3 ± 4.0 mmol/L, p <0.001), HOMA index (2.4 ± 0.8 and 1.6 ± 0.7, p <0.001), body mass index (22.6 ± 4.3 and 19.3 ± 3.9 kg/m2, p = 0.012), waist circumference (68 ± 11 and 61 ± 12 cm, p = 0.034), blood concentration of C-reactive protein (2.3 ± 1 and 0.9 ± 0.7 mg/ml, p <0.001), diastolic blood pressure (70 ± 7 and 65 ± 6 mm Hg, р = 0.028), uric acid (0.29 ± 0.06 and 0.21 ± 0.06 mmol/L, р = 0.021), glucose (4.8 ± 0.6 and 4.6 ± 0.6 mmol/L, p = 0.011), triglycerides (0.86 ± 0.37 and 0.72 ± 0.31 mmol/L, р = 0.017), and lower mean level values of highdensity lipoprotein cholesterol (1.38 ± 0.36 and 1.58 ± 0.31 mmol/L, p = 0.011) were noted. Multivariate regression analysis showed an independent relationship between the 25(ОН)D level, C-reactive protein level (β = -0.55, p <0.001), and HOMA index (β = -0.96, p < 0.001).Conclusion. A low vitamin D level in the blood serum in children is associated with the components of the metabolic syndrome.https://vsp.spr-journal.ru/jour/article/view/1757childrenvitamin dvitamin d deficiencymetabolic syndromeinsulin resistance, inflammation |
| spellingShingle | Svetlana I. Malyavskaya Аndrej V. Lebedev Galina N. Kostrova COMPONENTS OF THE METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS WITH DIFFERENT LEVELS OF VITAMIN D: A CROSS-SECTIONAL STUDY Вопросы современной педиатрии children vitamin d vitamin d deficiency metabolic syndrome insulin resistance, inflammation |
| title | COMPONENTS OF THE METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS WITH DIFFERENT LEVELS OF VITAMIN D: A CROSS-SECTIONAL STUDY |
| title_full | COMPONENTS OF THE METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS WITH DIFFERENT LEVELS OF VITAMIN D: A CROSS-SECTIONAL STUDY |
| title_fullStr | COMPONENTS OF THE METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS WITH DIFFERENT LEVELS OF VITAMIN D: A CROSS-SECTIONAL STUDY |
| title_full_unstemmed | COMPONENTS OF THE METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS WITH DIFFERENT LEVELS OF VITAMIN D: A CROSS-SECTIONAL STUDY |
| title_short | COMPONENTS OF THE METABOLIC SYNDROME IN CHILDREN AND ADOLESCENTS WITH DIFFERENT LEVELS OF VITAMIN D: A CROSS-SECTIONAL STUDY |
| title_sort | components of the metabolic syndrome in children and adolescents with different levels of vitamin d a cross sectional study |
| topic | children vitamin d vitamin d deficiency metabolic syndrome insulin resistance, inflammation |
| url | https://vsp.spr-journal.ru/jour/article/view/1757 |
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