Clinical and Phenotypic Characteristics of Early-Onset Inflammatory Bowel Disease: A Five-Year Observational Study
<b>Background:</b> Inflammatory bowel diseases with an early-onset form (EO-IBDs) make up a special disease group with certain clinical and phenotypic characteristics. This article discusses the features of such early onset in a group of children, based on five years of monitoring a regi...
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MDPI AG
2025-07-01
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| author | Ivan S. Samolygo Marina A. Manina Ekaterina A. Yablokova Pavel A. Stribul Alexander V. Novikov Anton S. Antishin Albina S. Pestova Alexander S. Tertychnyy Daniel Munblit Svetlana I. Erdes |
| author_facet | Ivan S. Samolygo Marina A. Manina Ekaterina A. Yablokova Pavel A. Stribul Alexander V. Novikov Anton S. Antishin Albina S. Pestova Alexander S. Tertychnyy Daniel Munblit Svetlana I. Erdes |
| author_sort | Ivan S. Samolygo |
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| description | <b>Background:</b> Inflammatory bowel diseases with an early-onset form (EO-IBDs) make up a special disease group with certain clinical and phenotypic characteristics. This article discusses the features of such early onset in a group of children, based on five years of monitoring a registry of children with IBD from a specialized center. <b>Methods:</b> This retrospective single-center cohort study included pediatric patients diagnosed with EO-IBD between 2019 and 2024. Clinical, laboratory, and endoscopic data were collected from medical records, including fecal calprotectin, inflammatory markers, disease activity indices, and endoscopic severity scores. Localization was classified according to the Paris system, and histological activity was assessed using the IBD-DCA score. <b>Results:</b> There were 20 patients with ulcerative colitis (UC) and 17 with Crohn’s disease (CD). Clinical activity was moderate or high (<i>p</i> = 0.179). UC was more characterized by diarrhea and rectal bleeding. CD was more often accompanied by abdominal pain, weight loss, and fever. In total, 82.4% of patients with CD had an inflammatory form. UC-like intestinal lesion was typical of both nosologies—L3 64.7% and E4 60% forms in CD and UC, respectively. Morphological activity was moderate for both nosologies (<i>p</i> = 0.54). IBD-U was present in 43.2% of patients. The median time after which it was possible to diagnose UC was 24 weeks (IQR 20–48) and 40 weeks (IQR 30–45.5) for CD (<i>p</i> = 0.56). <b>Conclusions:</b> Our study confirms the presence of characteristic signs of EO-IBD development, such as a frequent family history of IBD, high or moderate clinical activity during diagnosis verification, colon damage, and a high frequency of extraintestinal manifestations. |
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| issn | 2227-9067 |
| language | English |
| publishDate | 2025-07-01 |
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| spelling | doaj-art-8b6e7fdd35f84fe48fd8edcb0c9b6f4d2025-07-25T13:18:32ZengMDPI AGChildren2227-90672025-07-0112795210.3390/children12070952Clinical and Phenotypic Characteristics of Early-Onset Inflammatory Bowel Disease: A Five-Year Observational StudyIvan S. Samolygo0Marina A. Manina1Ekaterina A. Yablokova2Pavel A. Stribul3Alexander V. Novikov4Anton S. Antishin5Albina S. Pestova6Alexander S. Tertychnyy7Daniel Munblit8Svetlana I. Erdes9Department of Propaedeutics of Children’s Diseases, N.F. Filatov Clinical Institute of Children’s Health, I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya Str., 119991 Moscow, RussiaDepartment of Propaedeutics of Children’s Diseases, N.F. Filatov Clinical Institute of Children’s Health, I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya Str., 119991 Moscow, RussiaDepartment of Childhood Diseases, N.F. Filatov Clinical Institute of Child Health, I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya Str., 119991 Moscow, RussiaInstitute of Clinical Morphology and Digital Pathology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Lane, 1, Build. 1. Abrikosovskiy, 119435 Moscow, RussiaDepartment of Internal, Occupational Diseases and Rheumatology, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya Str., 119991 Moscow, RussiaDepartment of Propaedeutics of Children’s Diseases, N.F. Filatov Clinical Institute of Children’s Health, I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya Str., 119991 Moscow, RussiaDepartment of Propaedeutics of Children’s Diseases, N.F. Filatov Clinical Institute of Children’s Health, I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya Str., 119991 Moscow, RussiaInstitute of Clinical Morphology and Digital Pathology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Lane, 1, Build. 1. Abrikosovskiy, 119435 Moscow, RussiaCare for Long Term Conditions Division, Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King’s College London, Strand, London WC2R 2LS, UKDepartment of Propaedeutics of Children’s Diseases, N.F. Filatov Clinical Institute of Children’s Health, I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya Str., 119991 Moscow, Russia<b>Background:</b> Inflammatory bowel diseases with an early-onset form (EO-IBDs) make up a special disease group with certain clinical and phenotypic characteristics. This article discusses the features of such early onset in a group of children, based on five years of monitoring a registry of children with IBD from a specialized center. <b>Methods:</b> This retrospective single-center cohort study included pediatric patients diagnosed with EO-IBD between 2019 and 2024. Clinical, laboratory, and endoscopic data were collected from medical records, including fecal calprotectin, inflammatory markers, disease activity indices, and endoscopic severity scores. Localization was classified according to the Paris system, and histological activity was assessed using the IBD-DCA score. <b>Results:</b> There were 20 patients with ulcerative colitis (UC) and 17 with Crohn’s disease (CD). Clinical activity was moderate or high (<i>p</i> = 0.179). UC was more characterized by diarrhea and rectal bleeding. CD was more often accompanied by abdominal pain, weight loss, and fever. In total, 82.4% of patients with CD had an inflammatory form. UC-like intestinal lesion was typical of both nosologies—L3 64.7% and E4 60% forms in CD and UC, respectively. Morphological activity was moderate for both nosologies (<i>p</i> = 0.54). IBD-U was present in 43.2% of patients. The median time after which it was possible to diagnose UC was 24 weeks (IQR 20–48) and 40 weeks (IQR 30–45.5) for CD (<i>p</i> = 0.56). <b>Conclusions:</b> Our study confirms the presence of characteristic signs of EO-IBD development, such as a frequent family history of IBD, high or moderate clinical activity during diagnosis verification, colon damage, and a high frequency of extraintestinal manifestations.https://www.mdpi.com/2227-9067/12/7/952EO-IBDulcerative colitisCrohn’s diseasepediatric-onset IBD |
| spellingShingle | Ivan S. Samolygo Marina A. Manina Ekaterina A. Yablokova Pavel A. Stribul Alexander V. Novikov Anton S. Antishin Albina S. Pestova Alexander S. Tertychnyy Daniel Munblit Svetlana I. Erdes Clinical and Phenotypic Characteristics of Early-Onset Inflammatory Bowel Disease: A Five-Year Observational Study Children EO-IBD ulcerative colitis Crohn’s disease pediatric-onset IBD |
| title | Clinical and Phenotypic Characteristics of Early-Onset Inflammatory Bowel Disease: A Five-Year Observational Study |
| title_full | Clinical and Phenotypic Characteristics of Early-Onset Inflammatory Bowel Disease: A Five-Year Observational Study |
| title_fullStr | Clinical and Phenotypic Characteristics of Early-Onset Inflammatory Bowel Disease: A Five-Year Observational Study |
| title_full_unstemmed | Clinical and Phenotypic Characteristics of Early-Onset Inflammatory Bowel Disease: A Five-Year Observational Study |
| title_short | Clinical and Phenotypic Characteristics of Early-Onset Inflammatory Bowel Disease: A Five-Year Observational Study |
| title_sort | clinical and phenotypic characteristics of early onset inflammatory bowel disease a five year observational study |
| topic | EO-IBD ulcerative colitis Crohn’s disease pediatric-onset IBD |
| url | https://www.mdpi.com/2227-9067/12/7/952 |
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