Resveratrol Alleviates Inflammatory Response Through P2X7/NLRP3 Signaling Pathway: In Silico and In Vitro Evidence from Activated Microglia

Resveratrol Alleviates Inflammatory Response Through P2X7/NLRP3 Signaling Pathway: In Silico and In Vitro Evidence from Activated Microglia

<b>Background/Objectives</b>: Chronic inflammation and inappropriate NLRP3 inflammasome regulation are related to many brain diseases. Purinergic mediators may play an important role in inflammation regulation and could be targeted for effective therapies for these illnesses. We evaluate...

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Main Authors: Bianca Fagan Bissacotti, Marcylene Vieira da Silveira, Charles Elias Assmann, Priscila Marquezan Copetti, André Flores dos Santos, Solange Binotto Fagan, João Augusto Pereira da Rocha, Maria Rosa Chitolina Schetinger, Vera Maria Melchiors Morsch, Nathieli Bianchin Bottari, Alencar Kolinski Machado, Aleksandro Schafer da Silva
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceuticals
Subjects:
brain inflammation
BV-2 cells
immunomodulation
polyphenol
purinergic receptors
Online Access:https://www.mdpi.com/1424-8247/18/7/950
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