REPROGRAMMING OF SPLENIC MONONUCLEAR PHAGOCYTE PHENOTYPE DURING MODELING OF SYSTEMIC JUVENILE IDIOPATHIC ARTHRITISIN WISTAR RATS
Purpose. This study is devoted to the evaluation of the number of splenic alternatively activated (M2, CD163+) macrophages and other mononuclear phagocytes after arthritis development in a model of systemic juvenile arthritis in Wistar rats (with and without modification by doxycycline or dexamethaso...
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| Format: | Article |
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| Language: | Russian |
| Published: |
Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
2017-09-01
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| Series: | Сеченовский вестник |
| Subjects: | |
| Online Access: | https://www.sechenovmedj.com/jour/article/view/24 |
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| Summary: | Purpose. This study is devoted to the evaluation of the number of splenic alternatively activated (M2, CD163+) macrophages and other mononuclear phagocytes after arthritis development in a model of systemic juvenile arthritis in Wistar rats (with and without modification by doxycycline or dexamethasone). Methods. Cell phenotypes were assessed by flow cytometric analysis. Percentages of classically-activated phagocytes were estimated (M1, CD163-). Results. The indexes of dominating phenotypes are assessed for spleen (no significant differences in animal groups). In comparison we demonstrate indexes for the blood mononuclear phagocytes (significant changes were observed). Nevetherless, we have demonstrated phenotypical changes of splenic phagocyte population at whole. Conclusions. Redistribution of the tissue alternatively-activated cells of phagocyte population in spleen was found to be significantly different in animal groups with doxycycline and dexamethasone administration. |
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| ISSN: | 2218-7332 2658-3348 |