Polymorphic variant rs1739843 of heat shock protein beta-7 (HSPB7) gene and its relationship with on clinical profile and outcomes in patients with hypertrophic cardiomyopathy (results of a 10-year follow-up)
Aim. To determine the impact of polymorphic variant rs1739843 of the HSPB7 gene on clinical profile and outcomes in patients with hypertrophic cardiomyopathy (HCM).Material and methods. The study population consisted of 108 patients with HCM ≥45 years old. The control group included 192 healthy dono...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2019-11-01
|
| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/3155 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839576716097355776 |
|---|---|
| author | A. A. Streltsova A. Y. Gudkova A. A. Poliakova S. A. Pyko A. A. Kostareva |
| author_facet | A. A. Streltsova A. Y. Gudkova A. A. Poliakova S. A. Pyko A. A. Kostareva |
| author_sort | A. A. Streltsova |
| collection | DOAJ |
| description | Aim. To determine the impact of polymorphic variant rs1739843 of the HSPB7 gene on clinical profile and outcomes in patients with hypertrophic cardiomyopathy (HCM).Material and methods. The study population consisted of 108 patients with HCM ≥45 years old. The control group included 192 healthy donors. The design of the study included an assessment of the clinical course, determining the outcome of HCM using a new methodological approach proposed by Rowin EJ, et al. (2017). Polymorphic variant rs1739843 of the HSPB7 gene was genotyped by allele-specific real-time polymerase chain reaction (PCR) assay.Results. It was found a significant increase in frequency of TT genotype of rs1739843 of the HSPB7 gene in patients with HCM — 20,4%, compared with control group — 4,2% (ТТ: ТС+СС, odds ratio (OR) =5,88, 95% confidence interval (CI) =2,52-13,75, p<0,001). High prevalence of CC genotype of rs1739843 of the HSPB7 gene was observed in control group — 80,2% vs 31,5% in HCM group (CC: ТС+TT, OR=0,11, 95% CI=0,07-0,19, p<0,001). The allele frequency (С:Т) also differs between HCM and control groups — 55,6:44,4% in HCM vs 88,02:11,98% in control group (OR=5,88, 95% CI=3,91-8,85, p<0,001). It was also found a significant increase in frequency of TT genotype and T allele of rs1739843 of the HSPB7 gene in HCM patients with oligosymptomatic HCM course — 16,7%, compared with control group — 4,2% (ТТ: ТС+СС, OR=4,60, 95% CI=1,63-12,99, p<0,001). HCM patients ≥45 years old showed a significant increase in T allele frequency in cases of presence of 2 (FC III-IV CHF (chronic heart failure)+AF (atrial fibrillation), 18,8% vs 6,6%) and 3 adverse pathways (FC III-IV CHF+AF+SCD (sudden cardiac death), 4,2% vs 1,6%).Conclusion. HCM progression along 2 and more adverse pathways in patients ≥45 years old has been characterized with adverse outcome. The T allele and TT genotype of rs1739843 of the HSPB7 gene were more frequent in patients with HCM ≥45 years old, compared with control group. It was also found a significant increase in frequency of TT genotype and T allele of rs1739843 of the HSPB7 gene in HCM patients with oligosymptomatic HCM course, compared with control group.Allele T of rs1739843 of the HSPB7 gene is associated with 2 and more adverse pathways of HCM progression. |
| format | Article |
| id | doaj-art-8a0c0b33d10e43b29eb2605b816865d0 |
| institution | Matheson Library |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2019-11-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-8a0c0b33d10e43b29eb2605b816865d02025-08-04T13:00:21Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202019-11-0101071510.15829/1560-4071-2019-10-7-152611Polymorphic variant rs1739843 of heat shock protein beta-7 (HSPB7) gene and its relationship with on clinical profile and outcomes in patients with hypertrophic cardiomyopathy (results of a 10-year follow-up)A. A. Streltsova0A. Y. Gudkova1A. A. Poliakova2S. A. Pyko3A. A. Kostareva4Pavlov First Saint Petersburg State Medical UniversityPavlov First Saint Petersburg State Medical University; Almazov National Medical Research CenterPavlov First Saint Petersburg State Medical University; Almazov National Medical Research CenterSaint Petersburg Electrotechnical University “LETI”Pavlov First Saint Petersburg State Medical University; Almazov National Medical Research CenterAim. To determine the impact of polymorphic variant rs1739843 of the HSPB7 gene on clinical profile and outcomes in patients with hypertrophic cardiomyopathy (HCM).Material and methods. The study population consisted of 108 patients with HCM ≥45 years old. The control group included 192 healthy donors. The design of the study included an assessment of the clinical course, determining the outcome of HCM using a new methodological approach proposed by Rowin EJ, et al. (2017). Polymorphic variant rs1739843 of the HSPB7 gene was genotyped by allele-specific real-time polymerase chain reaction (PCR) assay.Results. It was found a significant increase in frequency of TT genotype of rs1739843 of the HSPB7 gene in patients with HCM — 20,4%, compared with control group — 4,2% (ТТ: ТС+СС, odds ratio (OR) =5,88, 95% confidence interval (CI) =2,52-13,75, p<0,001). High prevalence of CC genotype of rs1739843 of the HSPB7 gene was observed in control group — 80,2% vs 31,5% in HCM group (CC: ТС+TT, OR=0,11, 95% CI=0,07-0,19, p<0,001). The allele frequency (С:Т) also differs between HCM and control groups — 55,6:44,4% in HCM vs 88,02:11,98% in control group (OR=5,88, 95% CI=3,91-8,85, p<0,001). It was also found a significant increase in frequency of TT genotype and T allele of rs1739843 of the HSPB7 gene in HCM patients with oligosymptomatic HCM course — 16,7%, compared with control group — 4,2% (ТТ: ТС+СС, OR=4,60, 95% CI=1,63-12,99, p<0,001). HCM patients ≥45 years old showed a significant increase in T allele frequency in cases of presence of 2 (FC III-IV CHF (chronic heart failure)+AF (atrial fibrillation), 18,8% vs 6,6%) and 3 adverse pathways (FC III-IV CHF+AF+SCD (sudden cardiac death), 4,2% vs 1,6%).Conclusion. HCM progression along 2 and more adverse pathways in patients ≥45 years old has been characterized with adverse outcome. The T allele and TT genotype of rs1739843 of the HSPB7 gene were more frequent in patients with HCM ≥45 years old, compared with control group. It was also found a significant increase in frequency of TT genotype and T allele of rs1739843 of the HSPB7 gene in HCM patients with oligosymptomatic HCM course, compared with control group.Allele T of rs1739843 of the HSPB7 gene is associated with 2 and more adverse pathways of HCM progression.https://russjcardiol.elpub.ru/jour/article/view/3155hypertrophic cardiomyopathysyndromechronic heart failure with preserved ejection fractionpolymorphic variant rs1739843 of the hspb7 gene |
| spellingShingle | A. A. Streltsova A. Y. Gudkova A. A. Poliakova S. A. Pyko A. A. Kostareva Polymorphic variant rs1739843 of heat shock protein beta-7 (HSPB7) gene and its relationship with on clinical profile and outcomes in patients with hypertrophic cardiomyopathy (results of a 10-year follow-up) Российский кардиологический журнал hypertrophic cardiomyopathy syndrome chronic heart failure with preserved ejection fraction polymorphic variant rs1739843 of the hspb7 gene |
| title | Polymorphic variant rs1739843 of heat shock protein beta-7 (HSPB7) gene and its relationship with on clinical profile and outcomes in patients with hypertrophic cardiomyopathy (results of a 10-year follow-up) |
| title_full | Polymorphic variant rs1739843 of heat shock protein beta-7 (HSPB7) gene and its relationship with on clinical profile and outcomes in patients with hypertrophic cardiomyopathy (results of a 10-year follow-up) |
| title_fullStr | Polymorphic variant rs1739843 of heat shock protein beta-7 (HSPB7) gene and its relationship with on clinical profile and outcomes in patients with hypertrophic cardiomyopathy (results of a 10-year follow-up) |
| title_full_unstemmed | Polymorphic variant rs1739843 of heat shock protein beta-7 (HSPB7) gene and its relationship with on clinical profile and outcomes in patients with hypertrophic cardiomyopathy (results of a 10-year follow-up) |
| title_short | Polymorphic variant rs1739843 of heat shock protein beta-7 (HSPB7) gene and its relationship with on clinical profile and outcomes in patients with hypertrophic cardiomyopathy (results of a 10-year follow-up) |
| title_sort | polymorphic variant rs1739843 of heat shock protein beta 7 hspb7 gene and its relationship with on clinical profile and outcomes in patients with hypertrophic cardiomyopathy results of a 10 year follow up |
| topic | hypertrophic cardiomyopathy syndrome chronic heart failure with preserved ejection fraction polymorphic variant rs1739843 of the hspb7 gene |
| url | https://russjcardiol.elpub.ru/jour/article/view/3155 |
| work_keys_str_mv | AT aastreltsova polymorphicvariantrs1739843ofheatshockproteinbeta7hspb7geneanditsrelationshipwithonclinicalprofileandoutcomesinpatientswithhypertrophiccardiomyopathyresultsofa10yearfollowup AT aygudkova polymorphicvariantrs1739843ofheatshockproteinbeta7hspb7geneanditsrelationshipwithonclinicalprofileandoutcomesinpatientswithhypertrophiccardiomyopathyresultsofa10yearfollowup AT aapoliakova polymorphicvariantrs1739843ofheatshockproteinbeta7hspb7geneanditsrelationshipwithonclinicalprofileandoutcomesinpatientswithhypertrophiccardiomyopathyresultsofa10yearfollowup AT sapyko polymorphicvariantrs1739843ofheatshockproteinbeta7hspb7geneanditsrelationshipwithonclinicalprofileandoutcomesinpatientswithhypertrophiccardiomyopathyresultsofa10yearfollowup AT aakostareva polymorphicvariantrs1739843ofheatshockproteinbeta7hspb7geneanditsrelationshipwithonclinicalprofileandoutcomesinpatientswithhypertrophiccardiomyopathyresultsofa10yearfollowup |