Assessing functional suitability of a lyophilized formulation containing designed ankyrin repeat proteins for radionuclide imaging of HER2/neu overexpression in malignant tumors

Assessing functional suitability of a lyophilized formulation containing designed ankyrin repeat proteins for radionuclide imaging of HER2/neu overexpression in malignant tumors

Aim. To study in vitro and in vivo the functional suitability of 99mTc-labeled lyophilized formulation containing designed ankyrin repeat protein (DARPin) G3-(GGGS)3Cys for radionuclide imaging of HER2/neu overexpression in malignant tumors.Materials and methods. To create a targeted protein, a modi...

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Bibliographic Details
Main Authors: R. N. Varvashenya, A. A. Prach, E. V. Plotnikov, S. M. Deev, M. V. Belousov, M. S. Larkina, V. I. Chernov
Format: Article
Language:English
Published: Siberian State Medical University (Tomsk) 2024-10-01
Series:Бюллетень сибирской медицины
Subjects:
malignant tumors
her2/neu
radionuclide diagnosis
darpin g3
oxotechnetium
lyophilized formulation
Online Access:https://bulletin.ssmu.ru/jour/article/view/5733
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