Dysphagia and Mortality Risk in Individuals With Primary Progressive Apraxia of Speech

Dysphagia and Mortality Risk in Individuals With Primary Progressive Apraxia of Speech

ABSTRACT Individuals with primary progressive apraxia of speech (PPAOS) often develop parkinsonism and dysphagia. To evaluate the clinical correlates and impact of dysphagia in this population, we compared enrollment visit data between individuals with (n = 12) versus individuals without (n = 44) dy...

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Bibliographic Details
Main Authors: Gabriela Meade, Nha Trang Thu Pham, Sarah M. Boland, Heather M. Clark, Joseph R. Duffy, Jennifer L. Whitwell, Hugo Botha, Keith A. Josephs, Rene L. Utianski
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Annals of Clinical and Translational Neurology
Subjects:
cause of death
dysphagia
frontotemporal dementia
management
parkinsonism
Online Access:https://doi.org/10.1002/acn3.70056
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Summary:ABSTRACT Individuals with primary progressive apraxia of speech (PPAOS) often develop parkinsonism and dysphagia. To evaluate the clinical correlates and impact of dysphagia in this population, we compared enrollment visit data between individuals with (n = 12) versus individuals without (n = 44) dysphagia symptoms. The group with dysphagia had more motor speech symptoms and parkinsonism. Longitudinal analysis revealed that almost everyone developed dysphagia before dying; the average time to death after developing dysphagia was 5.43 years and complications of dysphagia resulted in mortality for 35% of the individuals for whom data were available. These results emphasize the need for dysphagia management and provide useful prognostic estimates.
ISSN:2328-9503

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