Impact of body weight on mycophenolic acid population pharmacokinetics in paediatric lupus nephritis: a pharmacogenomic integration study

Impact of body weight on mycophenolic acid population pharmacokinetics in paediatric lupus nephritis: a pharmacogenomic integration study

Background Mycophenolic acid (MPA) is recommended for the treatment of lupus nephritis (LN). However, the high pharmacokinetic (PK) variability of MPA contributes to its suboptimal efficacy and an increased incidence of adverse reactions. Rare data reported the impacts of genetic and clinical charac...

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Main Authors: Lu Zhang, Chen Ye, Yifan Zheng, Xiaoyun Jiang, Pan Chen, Kejing Tang, Baojing Liu, Lizhi Chen
Format: Article
Language:English
Published: BMJ Publishing Group 2025-07-01
Series:Lupus Science and Medicine
Online Access:https://lupus.bmj.com/content/12/2/e001535.full
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