PPE18 and PepA Variations in Mycobacterium tuberculosis Clinical Isolates from Makassar, Indonesia: Challenges for Immune Recognition and Vaccine Development

PPE18 and PepA Variations in Mycobacterium tuberculosis Clinical Isolates from Makassar, Indonesia: Challenges for Immune Recognition and Vaccine Development

Background: The M72/AS01E tuberculosis vaccine candidate, currently on trial in Indonesia, includes PPE18 (Rv1196) and PepA (Rv0125) as key antigens. Genetic variation in these proteins may affect immune recognition and vaccine efficacy. This study aims to analyse the genetic diversity of Rv1196 and...

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Main Authors: Stephanie Cynthia Theorupun, Muhammad Nasrum Massi, Astutiati Nurhasanah, Fadhilah Syamsuri, Mochammad Hatta, Yoeke Dewi Rasita, Najdah Hidayah, Nihayatul Karimah, Doddy Irawan Setyo Utomo
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-04-01
Series:International Journal of Mycobacteriology
Subjects:
antigen
mycobacterium tuberculosis
pepa
polymorphism
ppe18
rv0125
rv1196
vaccine candidate
Online Access:https://journals.lww.com/10.4103/ijmy.ijmy_70_25
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