CRISPR/Cas9-based discovery of ccRCC therapeutic opportunities through molecular mechanism and immune microenvironment analysis

CRISPR/Cas9-based discovery of ccRCC therapeutic opportunities through molecular mechanism and immune microenvironment analysis

IntroductionClear cell renal cell carcinoma is a common and aggressive form of renal cell carcinoma. Its incidence continues to rise, and metastatic recurrence leads to poor clinical outcomes. Current prognostic biomarkers lack reliability. We integrated multi-omics data to discover key ccRCC genes...

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Bibliographic Details
Main Authors: Bo Han, Weiyang Liu, Wanhui Wang, Zhuolun Li, Bosen You, Dongze Liu, Yunfeng Nan, Tiankai Ding, Zhou Dai, Yantong Zhang, Wei Zhang, Qing Liu, Xuedong Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
CRISPR-Cas9 screening
ccRCC
prognostic model
MELK
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1619361/full
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