Autologous Nanofragmented Lipoinjection (Nanofat) for the Treatment of Complex Anorectal Fistula Associated with Crohn's Disease
The management of complex anorectal fistulas associated with Crohn's Disease (CD) remains a significant clinical challenge, with current treatments achieving limited success in long-term remission. This article explores the application of autologous nanofragmented lipoinjection (Nanofat) for th...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2025-06-01
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| Series: | Journal of Coloproctology |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1809669 |
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| author | Alexandre Lopes de Carvalho Lina Maria Goes de Codes Alana Francisca Machado Melo Flávia de Castro Ribeiro Fidelis Bruna Fernandes Barreiro de Araújo Fabio Pereira Soares de Araújo Tiago Pereira de Castro José Valber Lima Meneses |
| author_facet | Alexandre Lopes de Carvalho Lina Maria Goes de Codes Alana Francisca Machado Melo Flávia de Castro Ribeiro Fidelis Bruna Fernandes Barreiro de Araújo Fabio Pereira Soares de Araújo Tiago Pereira de Castro José Valber Lima Meneses |
| author_sort | Alexandre Lopes de Carvalho |
| collection | DOAJ |
| description | The management of complex anorectal fistulas associated with Crohn's Disease (CD) remains a significant clinical challenge, with current treatments achieving limited success in long-term remission. This article explores the application of autologous nanofragmented lipoinjection (Nanofat) for the treatment of Perianal Fistulizing Crohn's Disease (PFCD). Nanofat, derived from adipose tissue and containing mesenchymal stem cells, offers the potential for tissue regeneration and immune modulation in the inflammatory environment of perianal CD. A patient with a chronic fistula, previously treated with Seton and maintained biologic therapy, underwent liposuction and nanofragmentation of adipose tissue. The resulting Nanofat was injected into the fistula tract following surgical debridement. The patient demonstrated complete healing with no recurrence of symptoms after six months, showcasing the efficacy of this technique. This autologous approach is low-cost, minimally invasive, and reproducible, with promising clinical outcomes. The addition of nanofragmented fat enhances tissue penetration and fat survival compared with traditional Microfat, increasing the chances of successful fistula repair. Further controlled studies comparing Nanofat with other established fistula repair methods are warranted to assess its long-term efficacy and standardize treatment protocols. |
| format | Article |
| id | doaj-art-8660d388eb8a4bb0a70a3a0cbb5ebb70 |
| institution | Matheson Library |
| issn | 2237-9363 2317-6423 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Journal of Coloproctology |
| spelling | doaj-art-8660d388eb8a4bb0a70a3a0cbb5ebb702025-06-27T00:27:48ZengThieme Revinter Publicações Ltda.Journal of Coloproctology2237-93632317-64232025-06-014502e1e410.1055/s-0045-1809669Autologous Nanofragmented Lipoinjection (Nanofat) for the Treatment of Complex Anorectal Fistula Associated with Crohn's DiseaseAlexandre Lopes de Carvalho0https://orcid.org/0000-0002-7122-5405Lina Maria Goes de Codes1https://orcid.org/0000-0002-0303-9926Alana Francisca Machado Melo2https://orcid.org/0009-0005-3592-7222Flávia de Castro Ribeiro Fidelis3https://orcid.org/0000-0003-1443-5024Bruna Fernandes Barreiro de Araújo4https://orcid.org/0000-0003-3729-8018Fabio Pereira Soares de Araújo5https://orcid.org/0009-0000-8615-8113Tiago Pereira de Castro6https://orcid.org/0009-0008-5760-7467José Valber Lima Meneses7https://orcid.org/0000-0001-5538-7108Department of Colorectal Surgery, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, BA, BrazilDepartment of Colorectal Surgery, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, BA, BrazilDepartment of Colorectal Surgery, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, BA, BrazilDepartment of Colorectal Surgery, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, BA, BrazilDepartment of Colorectal Surgery, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, BA, BrazilDepartment of Plastic Surgery, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, BA, BrazilDepartment of Plastic Surgery, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, BA, BrazilDepartment of Plastic Surgery, Professor Edgard Santos University Hospital, Federal University of Bahia, Salvador, BA, BrazilThe management of complex anorectal fistulas associated with Crohn's Disease (CD) remains a significant clinical challenge, with current treatments achieving limited success in long-term remission. This article explores the application of autologous nanofragmented lipoinjection (Nanofat) for the treatment of Perianal Fistulizing Crohn's Disease (PFCD). Nanofat, derived from adipose tissue and containing mesenchymal stem cells, offers the potential for tissue regeneration and immune modulation in the inflammatory environment of perianal CD. A patient with a chronic fistula, previously treated with Seton and maintained biologic therapy, underwent liposuction and nanofragmentation of adipose tissue. The resulting Nanofat was injected into the fistula tract following surgical debridement. The patient demonstrated complete healing with no recurrence of symptoms after six months, showcasing the efficacy of this technique. This autologous approach is low-cost, minimally invasive, and reproducible, with promising clinical outcomes. The addition of nanofragmented fat enhances tissue penetration and fat survival compared with traditional Microfat, increasing the chances of successful fistula repair. Further controlled studies comparing Nanofat with other established fistula repair methods are warranted to assess its long-term efficacy and standardize treatment protocols.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1809669Perianal Crohn's diseaseCrohn's diseasemesenchymal stem cellcell regenerative therapymicrofragmented adipose tissuenanofat |
| spellingShingle | Alexandre Lopes de Carvalho Lina Maria Goes de Codes Alana Francisca Machado Melo Flávia de Castro Ribeiro Fidelis Bruna Fernandes Barreiro de Araújo Fabio Pereira Soares de Araújo Tiago Pereira de Castro José Valber Lima Meneses Autologous Nanofragmented Lipoinjection (Nanofat) for the Treatment of Complex Anorectal Fistula Associated with Crohn's Disease Journal of Coloproctology Perianal Crohn's disease Crohn's disease mesenchymal stem cell cell regenerative therapy microfragmented adipose tissue nanofat |
| title | Autologous Nanofragmented Lipoinjection (Nanofat) for the Treatment of Complex Anorectal Fistula Associated with Crohn's Disease |
| title_full | Autologous Nanofragmented Lipoinjection (Nanofat) for the Treatment of Complex Anorectal Fistula Associated with Crohn's Disease |
| title_fullStr | Autologous Nanofragmented Lipoinjection (Nanofat) for the Treatment of Complex Anorectal Fistula Associated with Crohn's Disease |
| title_full_unstemmed | Autologous Nanofragmented Lipoinjection (Nanofat) for the Treatment of Complex Anorectal Fistula Associated with Crohn's Disease |
| title_short | Autologous Nanofragmented Lipoinjection (Nanofat) for the Treatment of Complex Anorectal Fistula Associated with Crohn's Disease |
| title_sort | autologous nanofragmented lipoinjection nanofat for the treatment of complex anorectal fistula associated with crohn s disease |
| topic | Perianal Crohn's disease Crohn's disease mesenchymal stem cell cell regenerative therapy microfragmented adipose tissue nanofat |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1809669 |
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