Cholangiocarcinoma-derived secreted products and growth arrest-specific 2-like 3 enhance migratory and invasive abilities of fibroblasts

Cholangiocarcinoma-derived secreted products and growth arrest-specific 2-like 3 enhance migratory and invasive abilities of fibroblasts

Cholangiocarcinoma (CCA) is a highly aggressive cancer with limited treatment options, which highlights the urgent need for alternative therapies. One hallmark of CCA is an increase in cancer-associated fibroblasts (CAFs) accompanied by a desmoplastic reaction and fibrosis. However, the roles of CCA...

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Main Authors: Natnicha Paungpan, Kulthida Vaeteewoottacharn, Paweena Dana, Saowaluk Saisomboon, Sittiruk Roytrakul, Wiphawi Hipkaeo, Yada Polsan, Kanlayanee Sawanyawisuth, Sukanya Luang, Worachart Lert-itthiporn, Vor Luvira, Chawalit Pairojkul, Yaovalux Chamgramol, Sopit Wongkham, Seiji Okada
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:European Journal of Cell Biology
Subjects:
Bile duct cancer
Cholangiocarcinoma
Fibroblast
Secreted products
Exosome
Growth arrest-specific 2-like 3
Online Access:http://www.sciencedirect.com/science/article/pii/S0171933525000329
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