CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses.

CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses.

Exacerbated and persistent innate immune response marked by pro-inflammatory cytokine expression is thought to be a major driver of chronic COVID-19 pathology. Although macrophages are not the primary target cells of SARS-CoV-2 infection in humans, viral RNA and antigens in activated monocytes and m...

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Main Authors: Sallieu Jalloh, Judith Olejnik, Jacob Berrigan, Annuurun Nisa, Ellen L Suder, Hisashi Akiyama, Maohua Lei, Sita Ramaswamy, Sanjay Tyagi, Yuri Bushkin, Elke Mühlberger, Suryaram Gummuluru
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-10-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010479&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010479&type=printable

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