Targeting DNA Damage Response-Mediated Resistance in Non-Small Cell Lung Cancer: From Mechanistic Insights to Drug Development

Targeting DNA Damage Response-Mediated Resistance in Non-Small Cell Lung Cancer: From Mechanistic Insights to Drug Development

Non-small cell lung cancer (NSCLC) remains a major contributor to cancer-related deaths worldwide, with therapeutic resistance presenting a critical clinical hurdle. The DNA damage response (DDR) constitutes a sophisticated cellular framework that detects, signals, and repairs genetic lesions to pre...

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Bibliographic Details
Main Authors: Xue Gong, Yongzhao Zhou, Yi Deng
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Current Oncology
Subjects:
non-small cell lung cancer
DNA damage response
drug resistance
radiotherapy
chemotherapy
targeted therapy
Online Access:https://www.mdpi.com/1718-7729/32/7/367
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