Association of the interaction between occupational hazard factors and IL-1β gene polymorphism with cognitive function in electrolytic aluminum workers
BackgroundVarious occupational hazards in the electrolytic aluminum environment have been linked to cognitive decline. However, the interactive effects of these hazards and genetic factors on cognitive function remain unclear.ObjectiveThis study aimed to identify the primary occupational hazards, ex...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2025.1591908/full |
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| author | Youxing Li Youxing Li Yaqin Pang Yaqin Pang Yaqin Pang Dongshun Chen Feiyu Lu Hongyan Tian Fengni Qin Kuntao Wei Ahmad Razali Bin Ishak Mohd Shukri Bin Mohd Aris Mohd Shukri Bin Mohd Aris Guangzi Qi |
| author_facet | Youxing Li Youxing Li Yaqin Pang Yaqin Pang Yaqin Pang Dongshun Chen Feiyu Lu Hongyan Tian Fengni Qin Kuntao Wei Ahmad Razali Bin Ishak Mohd Shukri Bin Mohd Aris Mohd Shukri Bin Mohd Aris Guangzi Qi |
| author_sort | Youxing Li |
| collection | DOAJ |
| description | BackgroundVarious occupational hazards in the electrolytic aluminum environment have been linked to cognitive decline. However, the interactive effects of these hazards and genetic factors on cognitive function remain unclear.ObjectiveThis study aimed to identify the primary occupational hazards, examine their interaction with IL-1β gene polymorphisms in relation to cognitive function.MethodsA cross-sectional study was conducted in June 2024 at an electrolytic aluminum company in China, involving 478 male workers. Cognitive function was assessed using the Montreal Cognitive Assessment. Calculate the cumulative exposure dose of harmful factors such as aluminum dust. Additionally, IL-1β gene polymorphisms (rs1143627, rs1143643, rs16944, rs3917356) and serum protein levels were analyzed. The associations between environmental exposure, genetic factors, and cognitive function were examined using multivariate stepwise linear regression, restricted cubic splines, generalized linear models, and hierarchical analysis. Covariance analysis and independent sample t-tests were employed to assess the potential mediating effect of peripheral blood IL-1β levels.ResultsCumulative exposure to aluminum dust was significantly associated with cognitive decline (β = −0.18, 95% CI: 0.27, −0.10), and the relationship was linear. Compared to the wild genotype, individuals carrying rs1143627 G/G, rs1143643 C/C, and rs16944 A/A exhibited significantly lower cognitive scores (P < 0.01), whereas rs3917356 C/T and T/T conferred a protective effect (P < 0.01). The model was adjusted for age, body mass index, and cumulative aluminum dust exposure. The genetic effect associated with IL-1β was more pronounced in individuals with high aluminum exposure (>2.37 mg/m3 × year). IL-1β serum protein levels showed no significant association with cognitive function (P > 0.05).ConclusionCumulative exposure to aluminum dust is a key risk factor for cognitive decline. IL-1β polymorphisms influence susceptibility, with the effect becoming more pronounced under high aluminum exposure. However, peripheral blood IL-1β levels do not mediate this association with cognitive decline. |
| format | Article |
| id | doaj-art-85aa7d831d9443f58d1b755da3e7b49b |
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| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-85aa7d831d9443f58d1b755da3e7b49b2025-06-25T04:10:37ZengFrontiers Media S.A.Frontiers in Genetics1664-80212025-06-011610.3389/fgene.2025.15919081591908Association of the interaction between occupational hazard factors and IL-1β gene polymorphism with cognitive function in electrolytic aluminum workersYouxing Li0Youxing Li1Yaqin Pang2Yaqin Pang3Yaqin Pang4Dongshun Chen5Feiyu Lu6Hongyan Tian7Fengni Qin8Kuntao Wei9Ahmad Razali Bin Ishak10Mohd Shukri Bin Mohd Aris11Mohd Shukri Bin Mohd Aris12Guangzi Qi13College of Public Health, Youjiang Medical University for Nationalities, Baise, Guangxi, ChinaFaculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam, MalaysiaKey Laboratory of Research on Environment and Population Health in aluminum mining areas (Youjiang Medical University for Nationalities), Education Department of Guangxi Zhuang Autonomous Region, Baise, ChinaKey Laboratory of Research on Environmental pollution and health risk assessment, Youjiang Medical University for Nationalities, Baise, Guangxi, ChinaCollege of Medical Laboratory Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi, ChinaCollege of Medical Laboratory Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi, ChinaCollege of Public Health, Youjiang Medical University for Nationalities, Baise, Guangxi, ChinaCollege of Public Health, Youjiang Medical University for Nationalities, Baise, Guangxi, ChinaCollege of Public Health, Youjiang Medical University for Nationalities, Baise, Guangxi, ChinaCollege of Public Health, Youjiang Medical University for Nationalities, Baise, Guangxi, ChinaFaculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam, MalaysiaFaculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam, MalaysiaOccupational Health and Safety Risk Management (OHSeRM) Research Initiative Group, Universiti Teknologi MARA, Puncak Alam, Selangor, MalaysiaCollege of Public Health, Youjiang Medical University for Nationalities, Baise, Guangxi, ChinaBackgroundVarious occupational hazards in the electrolytic aluminum environment have been linked to cognitive decline. However, the interactive effects of these hazards and genetic factors on cognitive function remain unclear.ObjectiveThis study aimed to identify the primary occupational hazards, examine their interaction with IL-1β gene polymorphisms in relation to cognitive function.MethodsA cross-sectional study was conducted in June 2024 at an electrolytic aluminum company in China, involving 478 male workers. Cognitive function was assessed using the Montreal Cognitive Assessment. Calculate the cumulative exposure dose of harmful factors such as aluminum dust. Additionally, IL-1β gene polymorphisms (rs1143627, rs1143643, rs16944, rs3917356) and serum protein levels were analyzed. The associations between environmental exposure, genetic factors, and cognitive function were examined using multivariate stepwise linear regression, restricted cubic splines, generalized linear models, and hierarchical analysis. Covariance analysis and independent sample t-tests were employed to assess the potential mediating effect of peripheral blood IL-1β levels.ResultsCumulative exposure to aluminum dust was significantly associated with cognitive decline (β = −0.18, 95% CI: 0.27, −0.10), and the relationship was linear. Compared to the wild genotype, individuals carrying rs1143627 G/G, rs1143643 C/C, and rs16944 A/A exhibited significantly lower cognitive scores (P < 0.01), whereas rs3917356 C/T and T/T conferred a protective effect (P < 0.01). The model was adjusted for age, body mass index, and cumulative aluminum dust exposure. The genetic effect associated with IL-1β was more pronounced in individuals with high aluminum exposure (>2.37 mg/m3 × year). IL-1β serum protein levels showed no significant association with cognitive function (P > 0.05).ConclusionCumulative exposure to aluminum dust is a key risk factor for cognitive decline. IL-1β polymorphisms influence susceptibility, with the effect becoming more pronounced under high aluminum exposure. However, peripheral blood IL-1β levels do not mediate this association with cognitive decline.https://www.frontiersin.org/articles/10.3389/fgene.2025.1591908/fulloccupational factorsaluminum dustIL-1βgenetic polymorphismcognitive functioninteraction |
| spellingShingle | Youxing Li Youxing Li Yaqin Pang Yaqin Pang Yaqin Pang Dongshun Chen Feiyu Lu Hongyan Tian Fengni Qin Kuntao Wei Ahmad Razali Bin Ishak Mohd Shukri Bin Mohd Aris Mohd Shukri Bin Mohd Aris Guangzi Qi Association of the interaction between occupational hazard factors and IL-1β gene polymorphism with cognitive function in electrolytic aluminum workers Frontiers in Genetics occupational factors aluminum dust IL-1β genetic polymorphism cognitive function interaction |
| title | Association of the interaction between occupational hazard factors and IL-1β gene polymorphism with cognitive function in electrolytic aluminum workers |
| title_full | Association of the interaction between occupational hazard factors and IL-1β gene polymorphism with cognitive function in electrolytic aluminum workers |
| title_fullStr | Association of the interaction between occupational hazard factors and IL-1β gene polymorphism with cognitive function in electrolytic aluminum workers |
| title_full_unstemmed | Association of the interaction between occupational hazard factors and IL-1β gene polymorphism with cognitive function in electrolytic aluminum workers |
| title_short | Association of the interaction between occupational hazard factors and IL-1β gene polymorphism with cognitive function in electrolytic aluminum workers |
| title_sort | association of the interaction between occupational hazard factors and il 1β gene polymorphism with cognitive function in electrolytic aluminum workers |
| topic | occupational factors aluminum dust IL-1β genetic polymorphism cognitive function interaction |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2025.1591908/full |
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