Effector Responses Induced by Pattern Recognition Receptors (PRRs) for Disease Protection
Background. Pattern Recognition Receptors (PRRs) represent fundamental components of the innate immune system responsible for detecting pathogenassociated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Understanding PRR-mediated effector responses is essential for devel...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Private institution educational organization of higher education "Medical University "ReaViz"
2025-08-01
|
| Series: | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| Subjects: | |
| Online Access: | https://vestnik.reaviz.ru/jour/article/view/1268 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839588299157536768 |
|---|---|
| author | L. Chi Ya. Chi |
| author_facet | L. Chi Ya. Chi |
| author_sort | L. Chi |
| collection | DOAJ |
| description | Background. Pattern Recognition Receptors (PRRs) represent fundamental components of the innate immune system responsible for detecting pathogenassociated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Understanding PRR-mediated effector responses is essential for developing therapeutic strategies and enhancing disease protection mechanisms. Objective. To comprehensively review the mechanisms of PRR activation, classification, and their pivotal role in orchestrating effector responses for disease protection, while examining their therapeutic implications and potential clinical applications. Methods. This review analyzes current literature on PRR biology, focusing on their classification into membrane-bound (Toll-like receptors, C-type lectin receptors), cytoplasmic (NOD-like receptors, RIG-I-like receptors), and soluble (collectins, pentraxins) types. The study examines intracellular signaling pathways, including MyD88-dependent and TRIF-dependent pathways, and their downstream effects on immune cell activation. Results. PRRs demonstrate remarkable versatility in detecting diverse microbial threats and initiating tailored immune responses. Upon activation, PRRs trigger complex signaling cascades involving NF-κB and interferon regulatory factors (IRFs), leading to cytokine production, inflammation, and immune cell recruitment. Different infection types (bacterial, viral, fungal, parasitic) elicit specific PRR-mediated responses: bacterial infections activate complement and promote phagocytosis; viral infections induce interferon production and cytotoxic T lymphocyte responses; fungal infections stimulate Th1-mediated immunity; and parasitic infections trigger eosinophil activation and Th2 responses. PRRs also play crucial regulatory roles, preventing hyperinflammation and promoting immune tolerance. Conclusions. PRRs function as master regulators of immune responses, serving not only as pathogen detectors but also as sophisticated coordinators of immune activation, tolerance, and resolution. While dysregulated PRR signaling contributes to autoimmunity and chronic inflammatory diseases, targeted modulation of PRR pathways offers promising therapeutic opportunities. Future research directions include exploring novel PRR subtypes, developing precision immunomodulatory therapies, and addressing challenges in translating PRR-based interventions from bench to bedside. Clinical Significance. Understanding PRR-mediated effector responses provides insights into disease pathogenesis, offers potential drug targets for infectious and inflammatory diseases, and supports the development of individualized treatment approaches for enhanced immune protection. |
| format | Article |
| id | doaj-art-85a93fc23d5643a69c9d68a2c75daa36 |
| institution | Matheson Library |
| issn | 2226-762X 2782-1579 |
| language | Russian |
| publishDate | 2025-08-01 |
| publisher | Private institution educational organization of higher education "Medical University "ReaViz" |
| record_format | Article |
| series | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| spelling | doaj-art-85a93fc23d5643a69c9d68a2c75daa362025-08-03T13:33:59ZrusPrivate institution educational organization of higher education "Medical University "ReaViz"Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье2226-762X2782-15792025-08-0115317218210.20340/vmi-rvz.2025.3.MORPH.5777Effector Responses Induced by Pattern Recognition Receptors (PRRs) for Disease ProtectionL. Chi0Ya. Chi1University of GlasgowUniversity of GlasgowBackground. Pattern Recognition Receptors (PRRs) represent fundamental components of the innate immune system responsible for detecting pathogenassociated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Understanding PRR-mediated effector responses is essential for developing therapeutic strategies and enhancing disease protection mechanisms. Objective. To comprehensively review the mechanisms of PRR activation, classification, and their pivotal role in orchestrating effector responses for disease protection, while examining their therapeutic implications and potential clinical applications. Methods. This review analyzes current literature on PRR biology, focusing on their classification into membrane-bound (Toll-like receptors, C-type lectin receptors), cytoplasmic (NOD-like receptors, RIG-I-like receptors), and soluble (collectins, pentraxins) types. The study examines intracellular signaling pathways, including MyD88-dependent and TRIF-dependent pathways, and their downstream effects on immune cell activation. Results. PRRs demonstrate remarkable versatility in detecting diverse microbial threats and initiating tailored immune responses. Upon activation, PRRs trigger complex signaling cascades involving NF-κB and interferon regulatory factors (IRFs), leading to cytokine production, inflammation, and immune cell recruitment. Different infection types (bacterial, viral, fungal, parasitic) elicit specific PRR-mediated responses: bacterial infections activate complement and promote phagocytosis; viral infections induce interferon production and cytotoxic T lymphocyte responses; fungal infections stimulate Th1-mediated immunity; and parasitic infections trigger eosinophil activation and Th2 responses. PRRs also play crucial regulatory roles, preventing hyperinflammation and promoting immune tolerance. Conclusions. PRRs function as master regulators of immune responses, serving not only as pathogen detectors but also as sophisticated coordinators of immune activation, tolerance, and resolution. While dysregulated PRR signaling contributes to autoimmunity and chronic inflammatory diseases, targeted modulation of PRR pathways offers promising therapeutic opportunities. Future research directions include exploring novel PRR subtypes, developing precision immunomodulatory therapies, and addressing challenges in translating PRR-based interventions from bench to bedside. Clinical Significance. Understanding PRR-mediated effector responses provides insights into disease pathogenesis, offers potential drug targets for infectious and inflammatory diseases, and supports the development of individualized treatment approaches for enhanced immune protection.https://vestnik.reaviz.ru/jour/article/view/1268pattern recognition receptors [d000067996]innate immunity [d007113]toll-like receptors [d051193]pathogen-associated molecular patterns [d000067997]damage-associated molecular patterns [d000067998]cytokines [d016207]inflammation [d007249]phagocytosis [d010587]signal transduction [d015398]nf-kappa b [d016328]interferons [d007372] |
| spellingShingle | L. Chi Ya. Chi Effector Responses Induced by Pattern Recognition Receptors (PRRs) for Disease Protection Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье pattern recognition receptors [d000067996] innate immunity [d007113] toll-like receptors [d051193] pathogen-associated molecular patterns [d000067997] damage-associated molecular patterns [d000067998] cytokines [d016207] inflammation [d007249] phagocytosis [d010587] signal transduction [d015398] nf-kappa b [d016328] interferons [d007372] |
| title | Effector Responses Induced by Pattern Recognition Receptors (PRRs) for Disease Protection |
| title_full | Effector Responses Induced by Pattern Recognition Receptors (PRRs) for Disease Protection |
| title_fullStr | Effector Responses Induced by Pattern Recognition Receptors (PRRs) for Disease Protection |
| title_full_unstemmed | Effector Responses Induced by Pattern Recognition Receptors (PRRs) for Disease Protection |
| title_short | Effector Responses Induced by Pattern Recognition Receptors (PRRs) for Disease Protection |
| title_sort | effector responses induced by pattern recognition receptors prrs for disease protection |
| topic | pattern recognition receptors [d000067996] innate immunity [d007113] toll-like receptors [d051193] pathogen-associated molecular patterns [d000067997] damage-associated molecular patterns [d000067998] cytokines [d016207] inflammation [d007249] phagocytosis [d010587] signal transduction [d015398] nf-kappa b [d016328] interferons [d007372] |
| url | https://vestnik.reaviz.ru/jour/article/view/1268 |
| work_keys_str_mv | AT lchi effectorresponsesinducedbypatternrecognitionreceptorsprrsfordiseaseprotection AT yachi effectorresponsesinducedbypatternrecognitionreceptorsprrsfordiseaseprotection |