Severe pigeon paramyxovirus 1 infection in a human case with probable post-COVID-19 condition

Severe pigeon paramyxovirus 1 infection in a human case with probable post-COVID-19 condition

Pigeon paramyxovirus 1 (PPMV-1) is an antigenic host variant of avian paramyxovirus 1. Sporadic outbreaks of PPMV-1 infection have occurred in pigeons in China; however, few cases of human PPMV-1 infection have been reported. The purpose of this article is to report a case of severe human PPMV-1 inf...

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Main Authors: Shujuan Cui, Hui Xiong, Zhaomin Feng, Yanhui Chu, Chengli Que, Jingning Qin, Yang Pan, Kunyao Yu, Lei Jia, Xi Yao, Jiping Liao, Da Huo, Cuiyan Guo, Hao Zhao, Meng Xu, Yanan Tian, Qing Peng, Fu Li, Hui Xu, Runsheng Hong, Daitao Zhang, Guangfa Wang, Peng Yang, George F. Gao, Quanyi Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Emerging Microbes and Infections
Subjects:
Pigeon paramyxovirus 1
severe acute respiratory syndrome coronavirus 2
human PPMV-1 infection
cross-species
surveillance
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2023.2251600
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Summary:Pigeon paramyxovirus 1 (PPMV-1) is an antigenic host variant of avian paramyxovirus 1. Sporadic outbreaks of PPMV-1 infection have occurred in pigeons in China; however, few cases of human PPMV-1 infection have been reported. The purpose of this article is to report a case of severe human PPMV-1 infection in an individual with probable post-COVID-19 syndrome (long COVID) who presented with rapidly progressing pulmonary infection. The patient was a 66-year-old man who was admitted to the intensive care unit 11 days after onset of pneumonia and recovered 64 days after onset. PPMV-1 was isolated from the patient’s sputum and in cloacal smear samples from domesticated pigeons belonging to the patient’s neighbour. Residual severe acute respiratory syndrome coronavirus 2 was detected in respiratory and anal swab samples from the patient. Sequencing analyses revealed that the PPMV-1 genome belonged to genotype VI.2.1.1.2.2 and had the 112RRQKRF117 motif in the cleavage site of the fusion protein, which is indicative of high virulence. This case of cross-species transmission of PPMV-1 from a pigeon to a human highlights the risk of severe PPMV-1 infection in immunocompromised patients, especially those with long COVID. Enhanced surveillance for increased risk of severe viral infection is warranted in this population.
ISSN:2222-1751

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