Implantation of an Artificial Intelligence Denoising Algorithm Using SubtlePET™ with Various Radiotracers: 18F-FDG, 68Ga PSMA-11 and 18F-FDOPA, Impact on the Technologist Radiation Doses

Implantation of an Artificial Intelligence Denoising Algorithm Using SubtlePET™ with Various Radiotracers: 18F-FDG, 68Ga PSMA-11 and 18F-FDOPA, Impact on the Technologist Radiation Doses

This study assesses the clinical deployment of SubtlePET™, a commercial AI-based denoising algorithm, across three radiotracers—<sup>18</sup>F-FDG, <sup>68</sup>Ga-PSMA-11, and <sup>18</sup>F-FDOPA—with the goal of improving image quality while reducing injected a...

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Bibliographic Details
Main Authors: Jules Zhang-Yin, Octavian Dragusin, Paul Jonard, Christian Picard, Justine Grangeret, Christopher Bonnier, Philippe P. Leveque, Joel Aerts, Olivier Schaeffer
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Journal of Imaging
Subjects:
AI-based denoising
radiotracer dose reduction
PET/CT imaging
technologist radiation exposure
Online Access:https://www.mdpi.com/2313-433X/11/7/234
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Summary:This study assesses the clinical deployment of SubtlePET™, a commercial AI-based denoising algorithm, across three radiotracers—<sup>18</sup>F-FDG, <sup>68</sup>Ga-PSMA-11, and <sup>18</sup>F-FDOPA—with the goal of improving image quality while reducing injected activity, technologist radiation exposure, and scan time. A retrospective analysis on a digital PET/CT system showed that SubtlePET™ enabled dose reductions exceeding 33% and time savings of over 25%. AI-enhanced images were rated interpretable in 100% of cases versus 65% for standard low-dose reconstructions. Notably, 85% of AI-enhanced scans received the maximum Likert quality score (5/5), indicating excellent diagnostic confidence and noise suppression, compared to only 50% with conventional reconstruction. The quantitative image quality improved significantly across all tracers, with SNR and CNR gains of 50–70%. Radiotracer dose reductions were particularly substantial in low-BMI patients (up to 41% for FDG), and the technologist exposure decreased for high-exposure roles. The daily patient throughput increased by an average of 4.84 cases. These findings support the robust integration of SubtlePET™ into routine clinical PET practice, offering improved efficiency, safety, and image quality without compromising lesion detectability.
ISSN:2313-433X

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