Synthesis and properties of a novel pH sensitive poly(N-vinyl-pyrrolidone-co-sulfadiazine) hydrogel
Sulfadiazine monomer (SDM) was synthesized by the reaction of sulfadiazine with acryloyl chloride. The SDM was characterized by 1H-NMR and IR spectra. A novel hydrogel with –SO2NH- group was obtained by the radical copolymerization of SDM with N-vinyl-pyrrolidone (NVP). Effects of the reaction tempe...
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| Format: | Article |
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| Language: | English |
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Budapest University of Technology and Economics
2007-03-01
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| Series: | eXPRESS Polymer Letters |
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| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0000044&mi=cd |
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| description | Sulfadiazine monomer (SDM) was synthesized by the reaction of sulfadiazine with acryloyl chloride. The SDM was characterized by 1H-NMR and IR spectra. A novel hydrogel with –SO2NH- group was obtained by the radical copolymerization of SDM with N-vinyl-pyrrolidone (NVP). Effects of the reaction temperature, reaction time, the monomer ratio, and the amount of the cross-linker on the pH sensitivity of the hydrogel were investigated. Results indicate that the hydrogel shows strong pH sensitivity in the pH range of 6.5 to 7.2. It also exhibits a good swelling reversibility at buffer solutions of pH 6.5 and 7.2. At last, drugs tests demonstrated the release effect of the hydrogel in pH range of 6.5 to 7.2. |
| format | Article |
| id | doaj-art-8577ec8e1df84698b51c763edde57e3d |
| institution | Matheson Library |
| issn | 1788-618X |
| language | English |
| publishDate | 2007-03-01 |
| publisher | Budapest University of Technology and Economics |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj-art-8577ec8e1df84698b51c763edde57e3d2025-08-02T12:46:35ZengBudapest University of Technology and EconomicseXPRESS Polymer Letters1788-618X2007-03-011316617210.3144/expresspolymlett.2007.26Synthesis and properties of a novel pH sensitive poly(N-vinyl-pyrrolidone-co-sulfadiazine) hydrogelSulfadiazine monomer (SDM) was synthesized by the reaction of sulfadiazine with acryloyl chloride. The SDM was characterized by 1H-NMR and IR spectra. A novel hydrogel with –SO2NH- group was obtained by the radical copolymerization of SDM with N-vinyl-pyrrolidone (NVP). Effects of the reaction temperature, reaction time, the monomer ratio, and the amount of the cross-linker on the pH sensitivity of the hydrogel were investigated. Results indicate that the hydrogel shows strong pH sensitivity in the pH range of 6.5 to 7.2. It also exhibits a good swelling reversibility at buffer solutions of pH 6.5 and 7.2. At last, drugs tests demonstrated the release effect of the hydrogel in pH range of 6.5 to 7.2.http://www.expresspolymlett.com/letolt.php?file=EPL-0000044&mi=cdPolymer gelspH-sensitivesulfadiazineN-vinyl-2-pyrrolidonedrug release |
| spellingShingle | Synthesis and properties of a novel pH sensitive poly(N-vinyl-pyrrolidone-co-sulfadiazine) hydrogel eXPRESS Polymer Letters Polymer gels pH-sensitive sulfadiazine N-vinyl-2-pyrrolidone drug release |
| title | Synthesis and properties of a novel pH sensitive poly(N-vinyl-pyrrolidone-co-sulfadiazine) hydrogel |
| title_full | Synthesis and properties of a novel pH sensitive poly(N-vinyl-pyrrolidone-co-sulfadiazine) hydrogel |
| title_fullStr | Synthesis and properties of a novel pH sensitive poly(N-vinyl-pyrrolidone-co-sulfadiazine) hydrogel |
| title_full_unstemmed | Synthesis and properties of a novel pH sensitive poly(N-vinyl-pyrrolidone-co-sulfadiazine) hydrogel |
| title_short | Synthesis and properties of a novel pH sensitive poly(N-vinyl-pyrrolidone-co-sulfadiazine) hydrogel |
| title_sort | synthesis and properties of a novel ph sensitive poly n vinyl pyrrolidone co sulfadiazine hydrogel |
| topic | Polymer gels pH-sensitive sulfadiazine N-vinyl-2-pyrrolidone drug release |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0000044&mi=cd |