Synthesis and properties of a novel pH sensitive poly(N-vinyl-pyrrolidone-co-sulfadiazine) hydrogel
Sulfadiazine monomer (SDM) was synthesized by the reaction of sulfadiazine with acryloyl chloride. The SDM was characterized by 1H-NMR and IR spectra. A novel hydrogel with –SO2NH- group was obtained by the radical copolymerization of SDM with N-vinyl-pyrrolidone (NVP). Effects of the reaction tempe...
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| Format: | Article |
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| Language: | English |
| Published: |
Budapest University of Technology and Economics
2007-03-01
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| Series: | eXPRESS Polymer Letters |
| Subjects: | |
| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0000044&mi=cd |
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| Summary: | Sulfadiazine monomer (SDM) was synthesized by the reaction of sulfadiazine with acryloyl chloride. The SDM was characterized by 1H-NMR and IR spectra. A novel hydrogel with –SO2NH- group was obtained by the radical copolymerization of SDM with N-vinyl-pyrrolidone (NVP). Effects of the reaction temperature, reaction time, the monomer ratio, and the amount of the cross-linker on the pH sensitivity of the hydrogel were investigated. Results indicate that the hydrogel shows strong pH sensitivity in the pH range of 6.5 to 7.2. It also exhibits a good swelling reversibility at buffer solutions of pH 6.5 and 7.2. At last, drugs tests demonstrated the release effect of the hydrogel in pH range of 6.5 to 7.2. |
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| ISSN: | 1788-618X |