Assessment of oral toxicity and safety profile of cyanidin: acute and subacute studies on anthocyanin
Aim: Purified anthocyanins lack a detailed safety profile, prompting the need for comprehensive oral toxicity research. Materials & methods: Sprague-Dawley rats aged 8 weeks received 300 mg/kg cyanidin orally for 14 days in acute toxicity (OECD 423). In the subacute study (OECD 407), adult SD ra...
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Taylor & Francis Group
2024-12-01
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| Series: | Future Science OA |
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| Online Access: | https://www.tandfonline.com/doi/10.2144/fsoa-2023-0322 |
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| author | Swathi Suresh Chitra Vellapandian |
| author_facet | Swathi Suresh Chitra Vellapandian |
| author_sort | Swathi Suresh |
| collection | DOAJ |
| description | Aim: Purified anthocyanins lack a detailed safety profile, prompting the need for comprehensive oral toxicity research. Materials & methods: Sprague-Dawley rats aged 8 weeks received 300 mg/kg cyanidin orally for 14 days in acute toxicity (OECD 423). In the subacute study (OECD 407), adult SD rats were administered 7.5, 15 and 30 mg/kg/day cyanidin orally for 28 days. Results: Acute toxicity indicated an LD50 exceeding 300 mg/kg/day without adverse effects. Subacute toxicity at 7.5–30 mg/kg/day showed well-tolerated responses in both genders. No significant alterations in organ weights, hematological parameters, liver/kidney functions or adverse histopathological findings were observed. Conclusion: Oral cyanidin administration demonstrated high safety and tolerance in rats, establishing a NOAEL at 30 mg/kg/day, affirming cyanidin's safety for oral use. |
| format | Article |
| id | doaj-art-8558a38e87f04f1588c1e82f25f4c7b6 |
| institution | Matheson Library |
| issn | 2056-5623 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj-art-8558a38e87f04f1588c1e82f25f4c7b62025-07-16T11:43:21ZengTaylor & Francis GroupFuture Science OA2056-56232024-12-0110110.2144/fsoa-2023-0322Assessment of oral toxicity and safety profile of cyanidin: acute and subacute studies on anthocyaninSwathi Suresh0Chitra Vellapandian1Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science & Technology, Kattankulathur, Chengalpattu, Tamil Nadu, 603203, IndiaDean, SRM College of Pharmacy, SRM Institute of Science & Technology, Kattankulathur, Chengalpattu,Tamil Nadu, 603203, IndiaAim: Purified anthocyanins lack a detailed safety profile, prompting the need for comprehensive oral toxicity research. Materials & methods: Sprague-Dawley rats aged 8 weeks received 300 mg/kg cyanidin orally for 14 days in acute toxicity (OECD 423). In the subacute study (OECD 407), adult SD rats were administered 7.5, 15 and 30 mg/kg/day cyanidin orally for 28 days. Results: Acute toxicity indicated an LD50 exceeding 300 mg/kg/day without adverse effects. Subacute toxicity at 7.5–30 mg/kg/day showed well-tolerated responses in both genders. No significant alterations in organ weights, hematological parameters, liver/kidney functions or adverse histopathological findings were observed. Conclusion: Oral cyanidin administration demonstrated high safety and tolerance in rats, establishing a NOAEL at 30 mg/kg/day, affirming cyanidin's safety for oral use.https://www.tandfonline.com/doi/10.2144/fsoa-2023-0322acuteanthocyanincyanidinOECDoral toxicitysubacute |
| spellingShingle | Swathi Suresh Chitra Vellapandian Assessment of oral toxicity and safety profile of cyanidin: acute and subacute studies on anthocyanin Future Science OA acute anthocyanin cyanidin OECD oral toxicity subacute |
| title | Assessment of oral toxicity and safety profile of cyanidin: acute and subacute studies on anthocyanin |
| title_full | Assessment of oral toxicity and safety profile of cyanidin: acute and subacute studies on anthocyanin |
| title_fullStr | Assessment of oral toxicity and safety profile of cyanidin: acute and subacute studies on anthocyanin |
| title_full_unstemmed | Assessment of oral toxicity and safety profile of cyanidin: acute and subacute studies on anthocyanin |
| title_short | Assessment of oral toxicity and safety profile of cyanidin: acute and subacute studies on anthocyanin |
| title_sort | assessment of oral toxicity and safety profile of cyanidin acute and subacute studies on anthocyanin |
| topic | acute anthocyanin cyanidin OECD oral toxicity subacute |
| url | https://www.tandfonline.com/doi/10.2144/fsoa-2023-0322 |
| work_keys_str_mv | AT swathisuresh assessmentoforaltoxicityandsafetyprofileofcyanidinacuteandsubacutestudiesonanthocyanin AT chitravellapandian assessmentoforaltoxicityandsafetyprofileofcyanidinacuteandsubacutestudiesonanthocyanin |