Intra-pyloric botulinum toxin injection improves liquid gastric emptying using 99mTc DTPA scintigraphy: a case report in a 2 years- old girl with idiopathic gastroparesis
Gastroparesis, characterized by delayed gastric emptying in the absence of mechanical obstruction, is a challenging condition to diagnose and treat in children due to limited pediatric-specific data. This case report presents a 15-month-old girl with recurrent and chronic vomiting since infancy, whi...
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Mashhad University of Medical Sciences
2025-07-01
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| Series: | Asia Oceania Journal of Nuclear Medicine and Biology |
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| Online Access: | https://aojnmb.mums.ac.ir/article_25824_1870d52c1326fd8a650dfa3314adceb1.pdf |
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| author | Khadijah Sumitro Andy Darma Tri Sucianti Stepanus Massora Alpha Athiyyah Reza Ranuh Subijanto Soedarmo |
| author_facet | Khadijah Sumitro Andy Darma Tri Sucianti Stepanus Massora Alpha Athiyyah Reza Ranuh Subijanto Soedarmo |
| author_sort | Khadijah Sumitro |
| collection | DOAJ |
| description | Gastroparesis, characterized by delayed gastric emptying in the absence of mechanical obstruction, is a challenging condition to diagnose and treat in children due to limited pediatric-specific data. This case report presents a 15-month-old girl with recurrent and chronic vomiting since infancy, which worsened upon the introduction of solid foods. Initial diagnostic evaluations, including esophagogastroduodenoscopy (EGD) and upper gastrointestinal contrast study, ruled out structural abnormalities. A gastric emptying scintigraphy (GES) with 99mTc DTPA confirmed significant gastric retention, leading to a diagnosis of idiopathic gastroparesis. Endoscopic intra-pyloric botulinum toxin injection (IPBI) was performed and resulting in significant symptom improvement. Post-procedure assessments revealed improved gastric emptying, with reduced retention at 60 and 180 minutes and a markedly decreased half-time (t1/2) was shown following the procedure. These findings highlight that IPBI may be a promising therapeutic option for pediatric idiopathic gastroparesis unresponsive to standard treatments. Further research is warranted to refine treatment protocols and evaluate long-term outcomes. |
| format | Article |
| id | doaj-art-8542d6acf1cc413e8b769b51ac9b941f |
| institution | Matheson Library |
| issn | 2322-5718 2322-5726 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Asia Oceania Journal of Nuclear Medicine and Biology |
| spelling | doaj-art-8542d6acf1cc413e8b769b51ac9b941f2025-06-25T05:17:52ZengMashhad University of Medical SciencesAsia Oceania Journal of Nuclear Medicine and Biology2322-57182322-57262025-07-0113219019410.22038/aojnmb.2025.84182.159925824Intra-pyloric botulinum toxin injection improves liquid gastric emptying using 99mTc DTPA scintigraphy: a case report in a 2 years- old girl with idiopathic gastroparesisKhadijah Sumitro0Andy Darma1Tri Sucianti2Stepanus Massora3Alpha Athiyyah4Reza Ranuh5Subijanto Soedarmo6Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaDivision of Nuclear Medicine, Department of Radiology, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaDivision of Nuclear Medicine, Department of Radiology, Dr. Soetomo General Academic Hospital, Surabaya, IndonesiaDepartment of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaGastroparesis, characterized by delayed gastric emptying in the absence of mechanical obstruction, is a challenging condition to diagnose and treat in children due to limited pediatric-specific data. This case report presents a 15-month-old girl with recurrent and chronic vomiting since infancy, which worsened upon the introduction of solid foods. Initial diagnostic evaluations, including esophagogastroduodenoscopy (EGD) and upper gastrointestinal contrast study, ruled out structural abnormalities. A gastric emptying scintigraphy (GES) with 99mTc DTPA confirmed significant gastric retention, leading to a diagnosis of idiopathic gastroparesis. Endoscopic intra-pyloric botulinum toxin injection (IPBI) was performed and resulting in significant symptom improvement. Post-procedure assessments revealed improved gastric emptying, with reduced retention at 60 and 180 minutes and a markedly decreased half-time (t1/2) was shown following the procedure. These findings highlight that IPBI may be a promising therapeutic option for pediatric idiopathic gastroparesis unresponsive to standard treatments. Further research is warranted to refine treatment protocols and evaluate long-term outcomes.https://aojnmb.mums.ac.ir/article_25824_1870d52c1326fd8a650dfa3314adceb1.pdfpediatricgastroparesisgastric emptying scintigraphyintra-pyloric botulinum toxin |
| spellingShingle | Khadijah Sumitro Andy Darma Tri Sucianti Stepanus Massora Alpha Athiyyah Reza Ranuh Subijanto Soedarmo Intra-pyloric botulinum toxin injection improves liquid gastric emptying using 99mTc DTPA scintigraphy: a case report in a 2 years- old girl with idiopathic gastroparesis Asia Oceania Journal of Nuclear Medicine and Biology pediatric gastroparesis gastric emptying scintigraphy intra-pyloric botulinum toxin |
| title | Intra-pyloric botulinum toxin injection improves liquid gastric emptying using 99mTc DTPA scintigraphy: a case report in a 2 years- old girl with idiopathic gastroparesis |
| title_full | Intra-pyloric botulinum toxin injection improves liquid gastric emptying using 99mTc DTPA scintigraphy: a case report in a 2 years- old girl with idiopathic gastroparesis |
| title_fullStr | Intra-pyloric botulinum toxin injection improves liquid gastric emptying using 99mTc DTPA scintigraphy: a case report in a 2 years- old girl with idiopathic gastroparesis |
| title_full_unstemmed | Intra-pyloric botulinum toxin injection improves liquid gastric emptying using 99mTc DTPA scintigraphy: a case report in a 2 years- old girl with idiopathic gastroparesis |
| title_short | Intra-pyloric botulinum toxin injection improves liquid gastric emptying using 99mTc DTPA scintigraphy: a case report in a 2 years- old girl with idiopathic gastroparesis |
| title_sort | intra pyloric botulinum toxin injection improves liquid gastric emptying using 99mtc dtpa scintigraphy a case report in a 2 years old girl with idiopathic gastroparesis |
| topic | pediatric gastroparesis gastric emptying scintigraphy intra-pyloric botulinum toxin |
| url | https://aojnmb.mums.ac.ir/article_25824_1870d52c1326fd8a650dfa3314adceb1.pdf |
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