A controlled study of Gd-EOB-DTPA-enhanced MRI compared with enhanced CT in assessing lesion status after TACE for hepatocellular carcinoma
ObjectiveThis study aims to evaluate the diagnostic capability of Gd-EOB-DTPA-enhanced MRI in assessing lesion status following transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC), in comparison to contrast-enhanced CT (CECT).MethodsA total of 56 patients with HCC who...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1602428/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839617122455519232 |
|---|---|
| author | Qichao Cheng Xuewen Peng Zhanyu Zhou Bowen Wang Jinlei Fan Liping Zuo Weiwei Lv Dexin Yu |
| author_facet | Qichao Cheng Xuewen Peng Zhanyu Zhou Bowen Wang Jinlei Fan Liping Zuo Weiwei Lv Dexin Yu |
| author_sort | Qichao Cheng |
| collection | DOAJ |
| description | ObjectiveThis study aims to evaluate the diagnostic capability of Gd-EOB-DTPA-enhanced MRI in assessing lesion status following transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC), in comparison to contrast-enhanced CT (CECT).MethodsA total of 56 patients with HCC who underwent Gd-EOB-DTPA-enhanced MRI and CECT scans post-TACE were initially enrolled. The ability of both imaging modalities to differentiate between surviving, new, or necrotic lesions was assessed, using digital subtraction angiography (DSA) or interventional diagnostic results as the reference standard. Detection rates were compared using the chi-square test, while sensitivity, specificity, and accuracy were analyzed with McNemar’s test.ResultsAfter applying inclusion and exclusion criteria, 48 patients were eventually included in the analysis. The reference standard identified 14 cases of surviving lesions, 19 of new lesions, and 15 of necrotic lesions. Gd-EOB-DTPA-enhanced MRI demonstrated a sensitivity of 93.9% (31/33), specificity of 100% (15/15), and a Youden index of 0.939, whereas CECT exhibited a sensitivity of 51.5% (17/33), specificity of 60.0% (9/15), and a Youden index of 0.115.ConclusionThe findings indicate that Gd-EOB-DTPA-enhanced MRI possesses superior diagnostic value for evaluating lesion status in HCC post-TACE compared to CECT, as evidenced by significant differences in sensitivity and specificity (p < 0.05). |
| format | Article |
| id | doaj-art-853d3e5f5c5046f78b736f5963f3df9d |
| institution | Matheson Library |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-853d3e5f5c5046f78b736f5963f3df9d2025-07-25T05:25:21ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.16024281602428A controlled study of Gd-EOB-DTPA-enhanced MRI compared with enhanced CT in assessing lesion status after TACE for hepatocellular carcinomaQichao ChengXuewen PengZhanyu ZhouBowen WangJinlei FanLiping ZuoWeiwei LvDexin YuObjectiveThis study aims to evaluate the diagnostic capability of Gd-EOB-DTPA-enhanced MRI in assessing lesion status following transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC), in comparison to contrast-enhanced CT (CECT).MethodsA total of 56 patients with HCC who underwent Gd-EOB-DTPA-enhanced MRI and CECT scans post-TACE were initially enrolled. The ability of both imaging modalities to differentiate between surviving, new, or necrotic lesions was assessed, using digital subtraction angiography (DSA) or interventional diagnostic results as the reference standard. Detection rates were compared using the chi-square test, while sensitivity, specificity, and accuracy were analyzed with McNemar’s test.ResultsAfter applying inclusion and exclusion criteria, 48 patients were eventually included in the analysis. The reference standard identified 14 cases of surviving lesions, 19 of new lesions, and 15 of necrotic lesions. Gd-EOB-DTPA-enhanced MRI demonstrated a sensitivity of 93.9% (31/33), specificity of 100% (15/15), and a Youden index of 0.939, whereas CECT exhibited a sensitivity of 51.5% (17/33), specificity of 60.0% (9/15), and a Youden index of 0.115.ConclusionThe findings indicate that Gd-EOB-DTPA-enhanced MRI possesses superior diagnostic value for evaluating lesion status in HCC post-TACE compared to CECT, as evidenced by significant differences in sensitivity and specificity (p < 0.05).https://www.frontiersin.org/articles/10.3389/fmed.2025.1602428/fullhepatocellular carcinomatranscatheter arterial chemoembolizationGd-EOB-DTPA-enhanced MRIcontrast-enhanced CTlesion status |
| spellingShingle | Qichao Cheng Xuewen Peng Zhanyu Zhou Bowen Wang Jinlei Fan Liping Zuo Weiwei Lv Dexin Yu A controlled study of Gd-EOB-DTPA-enhanced MRI compared with enhanced CT in assessing lesion status after TACE for hepatocellular carcinoma Frontiers in Medicine hepatocellular carcinoma transcatheter arterial chemoembolization Gd-EOB-DTPA-enhanced MRI contrast-enhanced CT lesion status |
| title | A controlled study of Gd-EOB-DTPA-enhanced MRI compared with enhanced CT in assessing lesion status after TACE for hepatocellular carcinoma |
| title_full | A controlled study of Gd-EOB-DTPA-enhanced MRI compared with enhanced CT in assessing lesion status after TACE for hepatocellular carcinoma |
| title_fullStr | A controlled study of Gd-EOB-DTPA-enhanced MRI compared with enhanced CT in assessing lesion status after TACE for hepatocellular carcinoma |
| title_full_unstemmed | A controlled study of Gd-EOB-DTPA-enhanced MRI compared with enhanced CT in assessing lesion status after TACE for hepatocellular carcinoma |
| title_short | A controlled study of Gd-EOB-DTPA-enhanced MRI compared with enhanced CT in assessing lesion status after TACE for hepatocellular carcinoma |
| title_sort | controlled study of gd eob dtpa enhanced mri compared with enhanced ct in assessing lesion status after tace for hepatocellular carcinoma |
| topic | hepatocellular carcinoma transcatheter arterial chemoembolization Gd-EOB-DTPA-enhanced MRI contrast-enhanced CT lesion status |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1602428/full |
| work_keys_str_mv | AT qichaocheng acontrolledstudyofgdeobdtpaenhancedmricomparedwithenhancedctinassessinglesionstatusaftertaceforhepatocellularcarcinoma AT xuewenpeng acontrolledstudyofgdeobdtpaenhancedmricomparedwithenhancedctinassessinglesionstatusaftertaceforhepatocellularcarcinoma AT zhanyuzhou acontrolledstudyofgdeobdtpaenhancedmricomparedwithenhancedctinassessinglesionstatusaftertaceforhepatocellularcarcinoma AT bowenwang acontrolledstudyofgdeobdtpaenhancedmricomparedwithenhancedctinassessinglesionstatusaftertaceforhepatocellularcarcinoma AT jinleifan acontrolledstudyofgdeobdtpaenhancedmricomparedwithenhancedctinassessinglesionstatusaftertaceforhepatocellularcarcinoma AT lipingzuo acontrolledstudyofgdeobdtpaenhancedmricomparedwithenhancedctinassessinglesionstatusaftertaceforhepatocellularcarcinoma AT weiweilv acontrolledstudyofgdeobdtpaenhancedmricomparedwithenhancedctinassessinglesionstatusaftertaceforhepatocellularcarcinoma AT dexinyu acontrolledstudyofgdeobdtpaenhancedmricomparedwithenhancedctinassessinglesionstatusaftertaceforhepatocellularcarcinoma AT qichaocheng controlledstudyofgdeobdtpaenhancedmricomparedwithenhancedctinassessinglesionstatusaftertaceforhepatocellularcarcinoma AT xuewenpeng controlledstudyofgdeobdtpaenhancedmricomparedwithenhancedctinassessinglesionstatusaftertaceforhepatocellularcarcinoma AT zhanyuzhou controlledstudyofgdeobdtpaenhancedmricomparedwithenhancedctinassessinglesionstatusaftertaceforhepatocellularcarcinoma AT bowenwang controlledstudyofgdeobdtpaenhancedmricomparedwithenhancedctinassessinglesionstatusaftertaceforhepatocellularcarcinoma AT jinleifan controlledstudyofgdeobdtpaenhancedmricomparedwithenhancedctinassessinglesionstatusaftertaceforhepatocellularcarcinoma AT lipingzuo controlledstudyofgdeobdtpaenhancedmricomparedwithenhancedctinassessinglesionstatusaftertaceforhepatocellularcarcinoma AT weiweilv controlledstudyofgdeobdtpaenhancedmricomparedwithenhancedctinassessinglesionstatusaftertaceforhepatocellularcarcinoma AT dexinyu controlledstudyofgdeobdtpaenhancedmricomparedwithenhancedctinassessinglesionstatusaftertaceforhepatocellularcarcinoma |