Gut microbiota-derived SCFAs and MetS-related nephropathy
Metabolic syndrome (MetS) is a group of complex disorders characterized by abnormalities in the metabolism of proteins, fats, carbohydrates, and other substances in the human body. The kidney plays a vital role in these metabolic processes. Similarly, metabolic disorders can lead to renal damage, wh...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1561271/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839636223624216576 |
|---|---|
| author | Xiaofang Tian Li Sun Shengjie Guo Liying Yuan Tang Zhang Chengqian Huang Tingting He Qianfeng Jiang Yizhou Zeng |
| author_facet | Xiaofang Tian Li Sun Shengjie Guo Liying Yuan Tang Zhang Chengqian Huang Tingting He Qianfeng Jiang Yizhou Zeng |
| author_sort | Xiaofang Tian |
| collection | DOAJ |
| description | Metabolic syndrome (MetS) is a group of complex disorders characterized by abnormalities in the metabolism of proteins, fats, carbohydrates, and other substances in the human body. The kidney plays a vital role in these metabolic processes. Similarly, metabolic disorders can lead to renal damage, which can affect both its structure and function. The human intestinal tract possesses an abundant and diverse gut microbial community that significantly influences the physiology and pathology of the host. Growing evidence suggests that gut microbiota-derived metabolites exhibit multiple effects (anti-inflammatory, antioxidant, and improvement of lipid metabolism) in MetS. Particularly, considerable research has suggested that gut microbiota-derived short-chain fatty acids (SCFAs) have an intimate relationship with MetS-related nephropathy. The functions of SCFAs are involved in modulating energy metabolism, regulating immune and inflammatory responses, and inhibiting oxidative stress and mitochondrial damage, which are mainly through the activation of transmembrane G protein-coupled receptors (GPRs) and the inhibition of Histone deacetylase activity (HDAC). Regarding MetS-related nephropathy, therapeutic studies of SCFAs have been conducted in both clinical investigations and animal experiments. However, the role of SCFAs in kidney damage caused by various metabolic disorders has not been fully elucidated. The aim of this article is to review the role of SCFAs in MetS-related nephropathy, which will provide a prospective therapy strategy for MetS-related nephropathy. |
| format | Article |
| id | doaj-art-8512954f24364b68a0b64d6272b45e97 |
| institution | Matheson Library |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-8512954f24364b68a0b64d6272b45e972025-07-08T05:26:34ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-07-011210.3389/fnut.2025.15612711561271Gut microbiota-derived SCFAs and MetS-related nephropathyXiaofang Tian0Li Sun1Shengjie Guo2Liying Yuan3Tang Zhang4Chengqian Huang5Tingting He6Qianfeng Jiang7Yizhou Zeng8Department of Nephrology, the First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, ChinaGuizhou Aerospace Hospital, Zunyi, Guizhou, ChinaDepartment of Nephrology, the First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, ChinaDepartment of Nephrology, the First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, ChinaDepartment of Nephrology, the First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, ChinaDepartment of Nephrology, the First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, ChinaDepartment of Nephrology, the First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, ChinaDepartment of Cardiology, the First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, ChinaDepartment of Urology, the First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, ChinaMetabolic syndrome (MetS) is a group of complex disorders characterized by abnormalities in the metabolism of proteins, fats, carbohydrates, and other substances in the human body. The kidney plays a vital role in these metabolic processes. Similarly, metabolic disorders can lead to renal damage, which can affect both its structure and function. The human intestinal tract possesses an abundant and diverse gut microbial community that significantly influences the physiology and pathology of the host. Growing evidence suggests that gut microbiota-derived metabolites exhibit multiple effects (anti-inflammatory, antioxidant, and improvement of lipid metabolism) in MetS. Particularly, considerable research has suggested that gut microbiota-derived short-chain fatty acids (SCFAs) have an intimate relationship with MetS-related nephropathy. The functions of SCFAs are involved in modulating energy metabolism, regulating immune and inflammatory responses, and inhibiting oxidative stress and mitochondrial damage, which are mainly through the activation of transmembrane G protein-coupled receptors (GPRs) and the inhibition of Histone deacetylase activity (HDAC). Regarding MetS-related nephropathy, therapeutic studies of SCFAs have been conducted in both clinical investigations and animal experiments. However, the role of SCFAs in kidney damage caused by various metabolic disorders has not been fully elucidated. The aim of this article is to review the role of SCFAs in MetS-related nephropathy, which will provide a prospective therapy strategy for MetS-related nephropathy.https://www.frontiersin.org/articles/10.3389/fnut.2025.1561271/fullgut microbiotashort-chain fatty acidsmetabolic syndromechronic kidney diseaseenergy metabolism |
| spellingShingle | Xiaofang Tian Li Sun Shengjie Guo Liying Yuan Tang Zhang Chengqian Huang Tingting He Qianfeng Jiang Yizhou Zeng Gut microbiota-derived SCFAs and MetS-related nephropathy Frontiers in Nutrition gut microbiota short-chain fatty acids metabolic syndrome chronic kidney disease energy metabolism |
| title | Gut microbiota-derived SCFAs and MetS-related nephropathy |
| title_full | Gut microbiota-derived SCFAs and MetS-related nephropathy |
| title_fullStr | Gut microbiota-derived SCFAs and MetS-related nephropathy |
| title_full_unstemmed | Gut microbiota-derived SCFAs and MetS-related nephropathy |
| title_short | Gut microbiota-derived SCFAs and MetS-related nephropathy |
| title_sort | gut microbiota derived scfas and mets related nephropathy |
| topic | gut microbiota short-chain fatty acids metabolic syndrome chronic kidney disease energy metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1561271/full |
| work_keys_str_mv | AT xiaofangtian gutmicrobiotaderivedscfasandmetsrelatednephropathy AT lisun gutmicrobiotaderivedscfasandmetsrelatednephropathy AT shengjieguo gutmicrobiotaderivedscfasandmetsrelatednephropathy AT liyingyuan gutmicrobiotaderivedscfasandmetsrelatednephropathy AT tangzhang gutmicrobiotaderivedscfasandmetsrelatednephropathy AT chengqianhuang gutmicrobiotaderivedscfasandmetsrelatednephropathy AT tingtinghe gutmicrobiotaderivedscfasandmetsrelatednephropathy AT qianfengjiang gutmicrobiotaderivedscfasandmetsrelatednephropathy AT yizhouzeng gutmicrobiotaderivedscfasandmetsrelatednephropathy |