Multi‐miRNAs‐Mediated Hepatic Lepr Axis Suppression: A Pparg–Dicer1 Pathway‐Driven Mechanism in Spermatogenesis for the Intergenerational Transmission of Paternal Metabolic Syndrome

Multi‐miRNAs‐Mediated Hepatic Lepr Axis Suppression: A Pparg–Dicer1 Pathway‐Driven Mechanism in Spermatogenesis for the Intergenerational Transmission of Paternal Metabolic Syndrome

Abstract Bisphenol A (BPA) is an “environmental obesogen” and this study aims to investigate the intergenerational impacts of BPA‐induced metabolic syndrome (MetS), specifically focusing on unraveling mechanisms. Exposure to BPA induces metabolic disorders in the paternal mice, which are then transm...

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Bibliographic Details
Main Authors: Yi Lin, Xiuye Ni, Lin Zhu, Yilong Lin, Cai Peng, Zhao Lei, Yihui Wang, Huan Wang, Xiang You, Juan Li, Heqing Shen, Jie Wei
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
bisphenol A
intergenerational transmission
leptin resistance
metabolic syndrome
microRNAs
Online Access:https://doi.org/10.1002/advs.202410831
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