NQO1 antagonizes PM2.5-induced apoptosis of Sertoli cells by activating the UPRmt pathway

NQO1 antagonizes PM2.5-induced apoptosis of Sertoli cells by activating the UPRmt pathway

The mechanism by which NQO1 antagonizes PM2.5-induced apoptosis in Sertoli cells through activation of the mitochondrial unfolded protein response (UPRmt) was investigated. A reproductive toxicity model was established using TM4 cells exposed to PM2.5 (50 μg/mL, 24 h). Transcriptome sequencing and b...

Full description

Saved in:
Bibliographic Details
Main Authors: Cao Wang, Qing Xiao, Mingchen Xiao, Yu Chu, Yaya Ai, Zhen Luo, Guangxu Zhou, Kaiyi Mao, Bin Liu
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
PM2.5
NQO1
Mitochondrial Unfolded Protein Response (UPRmt)
Sertoli cells
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325010747
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items