The association between smoking and the occurrence of hyperuricemia: A retrospective cohort study
Introduction A retrospective cohort study was conducted to study the association between smoking and hyperuricemia (HUA). Methods By collecting and analyzing clinical data of 3196 patients with undiagnosed HUA at baseline in Dalian Municipal Central Hospital of China between 1 January 2010 and 1 Ja...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2025-05-01
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| Series: | Tobacco Induced Diseases |
| Subjects: | |
| Online Access: | https://www.tobaccoinduceddiseases.org/The-association-between-smoking-and-the-occurrence-of-hyperuricemia-A-retrospective,204253,0,2.html |
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| Summary: | Introduction
A retrospective cohort study was conducted to study the association
between smoking and hyperuricemia (HUA).
Methods
By collecting and analyzing clinical data of 3196 patients with undiagnosed
HUA at baseline in Dalian Municipal Central Hospital of China between 1 January
2010 and 1 January 2021, patients were grouped according to baseline smoking
status and smoking index (the number of cigarettes smoked per day × number of
years of smoking). Cox regression analysis was used to perform univariable and
multivariable analyses of factors that may influence the occurrence of HUA. And
further stratification was performed.
Results
The median follow-up time was 3.62 years. A total of 485 (15.2%) patients
developed HUA (≥420 μmol/L). The incidence of HUA was significantly higher
in the smoking group than in the non-smoking group (p 0) groups and the smoking index 0 (0) group (p<0.05). Multifactorial
Cox regression analyses were performed separately and after adjustment for
relevant influences, the results showed that smoking was an independent risk
factor for the occurrence of HUA with a hazard ratio (HR) of 1.38 (95% CI:
1.11–1.72). And the smoking index groups 401–600 and ≥601 were independent
risk factors for the occurrence of HUA, with HRs of 1.46 (95% CI: 1.20–1.70) and
1.53 (95% CI: 1.06–2.22), respectively. The further stratified analysis revealed
that smoking remained an independent risk factor for the occurrence of HUA in
all subgroups, and the smoking index ≥601 group was also an independent risk
factor for the occurrence of HUA, with HRs greater than 1 (p<0.05).
Conclusions
Smoking is an independent risk factor for the occurrence of HUA and
is independent of gender, whether a woman is menopausal, body mass index
(BMI), and alcohol consumption. The smoking index ≥601 was an independent
risk factor for the occurrence of HUA. |
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| ISSN: | 1617-9625 |