A transgenic cell line with inducible transcription for studying (CGG)n repeat expansion mechanisms

A transgenic cell line with inducible transcription for studying (CGG)n repeat expansion mechanisms

There are more than 30 inherited human disorders connected with repeat expansion (myotonic dystrophy type I, Huntington’s disease, Fragile X syndrome). Fragile X syndrome is the most common reason for inherited intellectual disability in the human population. The ways of the expansion development re...

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Bibliographic Details
Main Authors: I. V. Grishchenko, A. A. Tulupov, Y. M. Rymareva, E. D. Petrovskiy, A. A. Savelov, A. M. Korostyshevskaya, Y. V. Maksimova, A. R. Shorina, E. M. Shitik, D. V. Yudkin
Format: Article
Language:English
Published: Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders 2021-03-01
Series:Вавиловский журнал генетики и селекции
Subjects:
hereditary intellectual disability
fragile x syndrome
repeat expansion
transcription
replication
transgenic cell lines
somatic instability
Online Access:https://vavilov.elpub.ru/jour/article/view/2924
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