Sphingomyelin-induced glucocorticoid receptor alterations lead to impaired presynaptic plasticity in acid sphingomyelinase deficient neurons

Sphingomyelin-induced glucocorticoid receptor alterations lead to impaired presynaptic plasticity in acid sphingomyelinase deficient neurons

Acid sphingomyelinase deficiency (ASMD) is a rare disease caused by mutations in the gene encoding ASM, an enzyme that degrades sphingomyelin (SM). In addition to SM accumulation, neuroinflammation and cognitive impairment are pathological hallmarks of neurovisceral ASMD. Since the glucocorticoid sy...

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Bibliographic Details
Main Authors: Sara Naya-Forcano, Ángel Gaudioso, Beatriz Soto-Huelin, Celia García-Vilela, César Venero, Edward H. Schuchman, José A. Esteban, María Dolores Ledesma
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neurobiology of Disease
Subjects:
Glucocorticoid receptors
Hydrocortisone
Acid sphingomyelinase deficiency
Sphingomyelin
Synapsin
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125002323
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http://www.sciencedirect.com/science/article/pii/S0969996125002323

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