Diagnostic challenges in pulmonary Langerhans cell histiocytosis: A case report of nodular presentation in an adult
Adult pulmonary Langerhans cell histiocytosis (PLCH) represents a poorly understood subset of LCH, primarily involving young to middle-aged smokers and accounting for approximately 3–5 % of adult diffuse lung diseases. This case report presents uncommon presentation of adult PLCH with nodular pulmon...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Respiratory Medicine Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007125000814 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839635684930879488 |
|---|---|
| author | Nouman Aziz Waseem Nabi Sukhrob Makhkamov Sadhna Kumari Dimitri Chepkunov Daye Chung Sonu Sahni |
| author_facet | Nouman Aziz Waseem Nabi Sukhrob Makhkamov Sadhna Kumari Dimitri Chepkunov Daye Chung Sonu Sahni |
| author_sort | Nouman Aziz |
| collection | DOAJ |
| description | Adult pulmonary Langerhans cell histiocytosis (PLCH) represents a poorly understood subset of LCH, primarily involving young to middle-aged smokers and accounting for approximately 3–5 % of adult diffuse lung diseases. This case report presents uncommon presentation of adult PLCH with nodular pulmonary lesions on a 40-year-old female with a history of asthma, systemic lupus erythematosus (SLE), and smoking. CT chest confirmed multiple bilateral pulmonary nodules, with the largest measuring up to 12 mm. Biopsy of the lung nodules demonstrated Langerhans cell infiltration, with immunohistochemical staining positive for CD1a and S100, confirming the diagnosis of PLCH. The report underscores the importance of considering PLCH in the differential diagnosis of pulmonary nodules, particularly in patients with a significant smoking history, and contributes to the growing body of knowledge regarding the diverse presentations of LCH in adults. |
| format | Article |
| id | doaj-art-82a2d7f91c384c55ac5c8ba4f2d2c6c4 |
| institution | Matheson Library |
| issn | 2213-0071 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj-art-82a2d7f91c384c55ac5c8ba4f2d2c6c42025-07-09T04:32:23ZengElsevierRespiratory Medicine Case Reports2213-00712025-01-0157102245Diagnostic challenges in pulmonary Langerhans cell histiocytosis: A case report of nodular presentation in an adultNouman Aziz0Waseem Nabi1Sukhrob Makhkamov2Sadhna Kumari3Dimitri Chepkunov4Daye Chung5Sonu Sahni6Wyckoff Heights Medical Center, Brooklyn, NY, USA; Corresponding author.Wyckoff Heights Medical Center, Brooklyn, NY, USAJefferson Health Northeast, Philadelphia, PA, USAWyckoff Heights Medical Center, Brooklyn, NY, USASt. George's University School of Medicine, GrenadaSt. George's University School of Medicine, GrenadaWyckoff Heights Medical Center, Brooklyn, NY, USAAdult pulmonary Langerhans cell histiocytosis (PLCH) represents a poorly understood subset of LCH, primarily involving young to middle-aged smokers and accounting for approximately 3–5 % of adult diffuse lung diseases. This case report presents uncommon presentation of adult PLCH with nodular pulmonary lesions on a 40-year-old female with a history of asthma, systemic lupus erythematosus (SLE), and smoking. CT chest confirmed multiple bilateral pulmonary nodules, with the largest measuring up to 12 mm. Biopsy of the lung nodules demonstrated Langerhans cell infiltration, with immunohistochemical staining positive for CD1a and S100, confirming the diagnosis of PLCH. The report underscores the importance of considering PLCH in the differential diagnosis of pulmonary nodules, particularly in patients with a significant smoking history, and contributes to the growing body of knowledge regarding the diverse presentations of LCH in adults.http://www.sciencedirect.com/science/article/pii/S2213007125000814 |
| spellingShingle | Nouman Aziz Waseem Nabi Sukhrob Makhkamov Sadhna Kumari Dimitri Chepkunov Daye Chung Sonu Sahni Diagnostic challenges in pulmonary Langerhans cell histiocytosis: A case report of nodular presentation in an adult Respiratory Medicine Case Reports |
| title | Diagnostic challenges in pulmonary Langerhans cell histiocytosis: A case report of nodular presentation in an adult |
| title_full | Diagnostic challenges in pulmonary Langerhans cell histiocytosis: A case report of nodular presentation in an adult |
| title_fullStr | Diagnostic challenges in pulmonary Langerhans cell histiocytosis: A case report of nodular presentation in an adult |
| title_full_unstemmed | Diagnostic challenges in pulmonary Langerhans cell histiocytosis: A case report of nodular presentation in an adult |
| title_short | Diagnostic challenges in pulmonary Langerhans cell histiocytosis: A case report of nodular presentation in an adult |
| title_sort | diagnostic challenges in pulmonary langerhans cell histiocytosis a case report of nodular presentation in an adult |
| url | http://www.sciencedirect.com/science/article/pii/S2213007125000814 |
| work_keys_str_mv | AT noumanaziz diagnosticchallengesinpulmonarylangerhanscellhistiocytosisacasereportofnodularpresentationinanadult AT waseemnabi diagnosticchallengesinpulmonarylangerhanscellhistiocytosisacasereportofnodularpresentationinanadult AT sukhrobmakhkamov diagnosticchallengesinpulmonarylangerhanscellhistiocytosisacasereportofnodularpresentationinanadult AT sadhnakumari diagnosticchallengesinpulmonarylangerhanscellhistiocytosisacasereportofnodularpresentationinanadult AT dimitrichepkunov diagnosticchallengesinpulmonarylangerhanscellhistiocytosisacasereportofnodularpresentationinanadult AT dayechung diagnosticchallengesinpulmonarylangerhanscellhistiocytosisacasereportofnodularpresentationinanadult AT sonusahni diagnosticchallengesinpulmonarylangerhanscellhistiocytosisacasereportofnodularpresentationinanadult |